Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EGMVLPTVWQPANWMCRLSN | peptide aptamer placed within thioredoxin A. Aptamer specifically binds to M2 pyruvate kinase and shifts the isoenzyme into its low affinity dimeric conformation | Homo sapiens | |
EGQLRHWGWAWSLASQNFSI | peptide aptamer placed within thioredoxin A. Aptamer specifically binds to M2 pyruvate kinase and shifts the isoenzyme into its low affinity dimeric conformation | Homo sapiens | |
additional information | screen of a galactose-inducible combinatorial peptide aptamer library consisting of specific 20-mer peptides placed within 12-kDa protein thioredoxin A identifies 14 aptamers which specifically bind to M2 pyruvate kinase and shift the isoenzyme into its low affinity dimeric conformation. The aptamer-induced dimerization and inactivation of M2 pyruvate kinase leads to a significant decrease in the pyruvate kinase mass-action ratio as well as ATP:ADP ratio in the target cells. The expression of M2-pyruvate kinase-binding peptide aptamers moderately reduces the growth of immortalized NIH3T3 cell populations by decelerating cell proliferation, but without affecting apoptotic cell death. The M2-PK-binding peptide aptamers also reduce the proliferation rate of human U-2 OS osteosarcoma cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
U2-OS cell | - |
Homo sapiens | - |