Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocytoma cell | low-grade astrocytoma | Mus musculus | - |
brain | - |
Mus musculus | - |
C2C12 cell | - |
Mus musculus | - |
glioblastoma multiforme cell | - |
Mus musculus | - |
pilocytic astrocytoma cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP + phosphoenolpyruvate | - |
Mus musculus | ATP + pyruvate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKM1 | adult pyruvate kinase isoform | Mus musculus |
PKM2 | embryonic pyruvate kinase isoform | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ADP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
metabolism | the embryonic pyruvate kinase isoform PKM2 is almost universally re-expressed in cancer and promotes aerobic glycolysis, whereas the adult isoform PKM1 promotes oxidative phosphorylation | Mus musculus |