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Literature summary for 2.7.1.45 extracted from

  • Cynkin, M.A.; Ashwell, G.
    Uronic acid metabolism in bacteria: IV. Purification and properties of 2-keto-3-deoxy-D-gluconokinase in Escherichia coli (1969), J. Biol. Chem., 235, 1576-1579.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Mn2+ divalent cation required, most effective at a ratio of Mn2+ and ATP of 1:3, deviation from this ratio is inhibitory at several concentration levels Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1
-
2-dehydro-3-deoxy-D-gluconate
-
Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ divalent cation required Escherichia coli
Mg2+ divalent cation required Escherichia coli
Mn2+ divalent cation required, most effective at a ratio of Mn2+ and ATP of 1:3, deviation from this ratio is inhibitory at several concentration levels Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Klebsiella aerogenes
-
-
-
no activity in Azobacter agilis
-
-
-
no activity in Neurospora crassa
-
-
-
no activity in Salmonella typhimurium
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
assay method Escherichia coli

Storage Stability

Storage Stability Organism
-15°C, retains more than 50% of activity after 2 weeks Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2-dehydro-3-deoxy-D-gluconate
-
Escherichia coli ADP + 6-phospho-2-dehydro-3-deoxy-D-gluconate
-
?
ATP + 2-dehydro-3-deoxy-D-gluconate
-
Klebsiella aerogenes ADP + 6-phospho-2-dehydro-3-deoxy-D-gluconate
-
?
CTP + 2-dehydro-3-deoxy-D-gluconate 8% of the activity with ATP Escherichia coli CDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate
-
?
CTP + 2-dehydro-3-deoxy-D-gluconate 8% of the activity with ATP Klebsiella aerogenes CDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate
-
?
GTP + 2-dehydro-3-deoxy-D-gluconate 34% of the activity with ATP Escherichia coli GDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate
-
?
GTP + 2-dehydro-3-deoxy-D-gluconate 34% of the activity with ATP Klebsiella aerogenes GDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate
-
?
ITP + 2-dehydro-3-deoxy-D-gluconate 75% of the activity with ATP Escherichia coli IDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate
-
?
ITP + 2-dehydro-3-deoxy-D-gluconate 75% of the activity with ATP Klebsiella aerogenes IDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate
-
?
UTP + 2-dehydro-3-deoxy-D-gluconate 7% of the activity with ATP Escherichia coli UDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate
-
?
UTP + 2-dehydro-3-deoxy-D-gluconate 7% of the activity with ATP Klebsiella aerogenes UDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.6 6 acetate buffer Escherichia coli

pH Range

pH Minimum pH Maximum Comment Organism
4.7 8 pH 4.7: about 50% of maximum activity, pH 8: about 85% of maximum activity, acetate buffer Escherichia coli