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Literature summary for 2.7.1.60 extracted from

  • Krause, S.; Hinderlich, S.; Amsili, S.; Horstkorte, R.; Wiendl, H.; Argov, Z.; Mitrani-Rosenbaum, S.; Lochmueller, H.
    Localization of UDP-GlcNAc 2-epimerase/ManAc kinase (GNE) in the Golgi complex and the nucleus of mammalian cells (2005), Exp. Cell Res., 304, 365-379.
    View publication on PubMed
Search for more literature for 2.7.1.60

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HeLa cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus associated Mus musculus 5794
-
Golgi apparatus associated Homo sapiens 5794
-
nucleus associated Mus musculus 5634
-
nucleus HeLa and muscle cells Homo sapiens 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
79000
-
 x * 79000, SDS-PAGE Mus musculus
79000
-
 x * 79000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + N-acyl-D-mannosamine Mus musculus key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, essential for early embryonic development ADP + N-acyl-D-mannosamine 6-phosphate
-
 ?
ATP + N-acyl-D-mannosamine Homo sapiens key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, essential for early embryonic development, enzyme involved in several genetic disorders such as sialuria, hereditary inclusion body myopathy, and Nonaka myopathy ADP + N-acyl-D-mannosamine 6-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebellum
-
 Mus musculus
-
cerebrum
-
 Mus musculus
-
embryonic stem cell homozygous or heterozygous gene knock-out cells Mus musculus
-
HEK-293 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
JURKAT cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-
liver
-
 Mus musculus
-
myoblast
-
 Homo sapiens
-
skeletal muscle
-
 Mus musculus
-
TE-671 cell
-
 Homo sapiens
-
testis
-
 Mus musculus
-
thymus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + N-acyl-D-mannosamine
-
 Mus musculus ADP + N-acyl-D-mannosamine 6-phosphate
-
 ?
ATP + N-acyl-D-mannosamine
-
 Homo sapiens ADP + N-acyl-D-mannosamine 6-phosphate
-
 ?
ATP + N-acyl-D-mannosamine key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, essential for early embryonic development Mus musculus ADP + N-acyl-D-mannosamine 6-phosphate
-
 ?
ATP + N-acyl-D-mannosamine key enzyme in the synthesis of N-acetylneuraminic acid and therefore of nearly all other sialic acids, essential for early embryonic development, enzyme involved in several genetic disorders such as sialuria, hereditary inclusion body myopathy, and Nonaka myopathy Homo sapiens ADP + N-acyl-D-mannosamine 6-phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 79000, SDS-PAGE Mus musculus
? x * 79000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
UDP-GlcNAc 2-epimerase/ManNAc kinase
-
 Mus musculus
UDP-GlcNAc 2-epimerase/ManNAc kinase
-
 Homo sapiens
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase two different enzyme activities combined in a single bifunctional enzyme Mus musculus
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase two different enzyme activities combined in a single bifunctional enzyme Homo sapiens