Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.67 extracted from

  • Colodzin, M.; Kennedy, E.P.
    Biosynthesis of diphosphoinositide in brain (1965), J. Biol. Chem., 240, 3771-3780.
    View publication on PubMed
Search for more literature for 2.7.1.67

Activating Compound

Activating Compound Comment Organism Structure
inosithin at low concentrations Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Ca2+
-
 Rattus norvegicus
inosithin a commercial preparation of ethanol-insoluble phospholipids from soybean; at high concentration Rattus norvegicus
iodoacetate 0.1 mM, complete loss of activity Rattus norvegicus
NaF 60 mM, 73% inhibition Rattus norvegicus
NEM 0.1 mM, complete loss of activity Rattus norvegicus
PCMB 0.1 mM, complete loss of activity Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ Mg2+ or Mn2+ required. Mg2+ at 15 mM gives maximal activity with 5 mM ATP Rattus norvegicus
Mn2+ Mg2+ or Mn2+ required Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
heart
-
 Rattus norvegicus
-
kidney
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-
lung
-
 Rattus norvegicus
-
spleen
-
 Rattus norvegicus
-

Storage Stability

Storage Stability Organism
-20°C, 6 months, 50% loss of activity Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-phosphatidyl-1D-myo-inositol
-
 Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.3
-
-
 Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
6.3 8.7 pH 6.3: about 50% of maximal activity, pH 8.7: about 80% of maximal activity Rattus norvegicus