Literature summary for 2.7.1.67 extracted from

Shelton, S.N.; Barylko, B.; Binns, D.D.; Horazdovsky, B.F.; Albanesi, J.P.; Goodman, J.M.
Saccharomyces cerevisiae contains a type II phosphoinositide 4-kinase (2003), Biochem. J., 371, 533-540.

Search for more literature for 2.7.1.67

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Sf9 cells	Saccharomyces cerevisiae

Inhibitors

Inhibitors	Comment	Organism	Structure
adenosine	IC50: 0.15 mM	Saccharomyces cerevisiae
additional information	insensitive to inhibition by wortmannin	Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.266	-	ATP	-	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	vacuolar	Saccharomyces cerevisiae	16020	-
plasma membrane	-	Saccharomyces cerevisiae	5886	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 1-phosphatidyl-1D-myo-inositol	Saccharomyces cerevisiae	the enzyme plays a role in endocytic or exocytic pathways	ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 1-phosphatidyl-1D-myo-inositol	-	Saccharomyces cerevisiae	ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate	-	?
ATP + 1-phosphatidyl-1D-myo-inositol	the enzyme plays a role in endocytic or exocytic pathways	Saccharomyces cerevisiae	ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
Lsb6p	-	Saccharomyces cerevisiae
PI 4-kinase	-	Saccharomyces cerevisiae
type II phosphoinositide 4-kinase	-	Saccharomyces cerevisiae

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.15	-	IC50: 0.15 mM	Saccharomyces cerevisiae	adenosine

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Release 2023.1 (January 2023)