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Literature summary for 2.7.1.67 extracted from
- The role of phosphatidylinositol 4-kinases and phosphatidylinositol 4-phosphate during viral replication (2012), Biochem. Pharmacol., 84, 1400-1408.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | elevated phosphatidylinositol kinase activity in Rous sarcoma virus-transformed and in Eppstein Barr virus-infected cells | Homo sapiens |
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | type II phosphatidylinositol 4-kinases are promising targets for therapeutic intervention against viral infections, detailed overview | Homo sapiens |
| pharmacology | type II phosphatidylinositol 4-kinases are promising targets for therapeutic intervention against viral infections, detailed overview | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-amino-1-(isopropylsulfonyl)-6-benzimidazole phenylketone oxime | i.e. enviroxime, inhibitor of the in vitro replication of rhinoviruses and enteroviruses, inhibits hepatitis C virus subgenomic replicon replication | Homo sapiens |  |
| Cpd 6 | - |
Homo sapiens | |
| N-(5-[4-chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl]-4-methyl-1,3-thiazol-2-yl)acetamide | i.e. PIK93, a phenylthiazole | Homo sapiens | |
| tert-butyl N-[[8-(2-chlorophenyl)-4,5-dihydro[1,3]thiazolo[4,5-h]quinazolin-2-yl]carbamoyl]-beta-alaninate | i.e. Inhibitor A | Homo sapiens | |
| [5-(4-[[4-(morpholin-4-yl)phenyl]amino]quinazolin-6-yl)furan-2-yl]methanol | i.e. AL-9 | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | type II PI 4-kinase enzymes | Homo sapiens | 16020 | - |
| plasma membrane | type II PI 4-kinase enzymes | Homo sapiens | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
| additional information | Homo sapiens | the 3A protein from multiple picornaviruses, ncluding Aichi virus, bovine kobuvirus, CVB, HRV14, poliovirus, associates with isozyme PI4KIIIbeta and ACBD3 | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| B-lymphocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
| additional information | the 3A protein from multiple picornaviruses, ncluding Aichi virus, bovine kobuvirus, CVB, HRV14, poliovirus, associates with isozyme PI4KIIIbeta and ACBD3 | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phosphatidylinositol 4-kinase | - |
Homo sapiens |
| phosphatidylinositol 4-kinase IIIbeta | - |
Homo sapiens |
| PI4KIIIbeta | - |
Homo sapiens |
| type II PI 4-kinase enzyme | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000019 | - |
isozyme PI4KIIIbeta, pH and temperature not specified in the publication | Homo sapiens | N-(5-[4-chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl]-4-methyl-1,3-thiazol-2-yl)acetamide | |
| 0.000024 | - |
isozyme PI4KIIIbeta, pH and temperature not specified in the publication | Homo sapiens | Cpd 6 | |
| 0.00012 | - |
isozyme PI4KIIIbeta, pH and temperature not specified in the publication | Homo sapiens | 2-amino-1-(isopropylsulfonyl)-6-benzimidazole phenylketone oxime | |
| 0.00045 | - |
isozyme PI4KIIIalpha, pH and temperature not specified in the publication | Homo sapiens | tert-butyl N-[[8-(2-chlorophenyl)-4,5-dihydro[1,3]thiazolo[4,5-h]quinazolin-2-yl]carbamoyl]-beta-alaninate | |
| 0.00057 | - |
isozyme PI4KIIIalpha, pH 7.5, 22°C | Homo sapiens | [5-(4-[[4-(morpholin-4-yl)phenyl]amino]quinazolin-6-yl)furan-2-yl]methanol | |
| 0.0011 | - |
isozyme PI4KIIIalpha, pH and temperature not specified in the publication | Homo sapiens | N-(5-[4-chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl]-4-methyl-1,3-thiazol-2-yl)acetamide | |
| 0.0014 | - |
isozyme PI4KIIIalpha, pH and temperature not specified in the publication | Homo sapiens | 2-amino-1-(isopropylsulfonyl)-6-benzimidazole phenylketone oxime | |
| 0.0031 | - |
isozyme PI4KIIIbeta, pH 7.5, 22°C | Homo sapiens | [5-(4-[[4-(morpholin-4-yl)phenyl]amino]quinazolin-6-yl)furan-2-yl]methanol | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | silencing of isozyme PI4KIIIbeta, but not ofisozyme PI4KIIIa strongly inhibits SARS CoV spike-mediated entry | Homo sapiens |
| physiological function | PI4KIIIalpha is a host factor for hepatitis C virus. Isozyme PI4KIIIbet is involved in the entry of SARS coronavirus. PI4KIIIbeta is not required for virus binding and internalization, but plays a role at, or before, virus fusion with the late endosomes. Modes of recruitment of PI4KIIIs to the replication complexes of hepattis C virus, enteroviruses, and the Aichi virus, overview | Homo sapiens |
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