Any feedback?
Literature summary for 2.7.1.67 extracted from
- Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer (2012), Cancer Lett., 325, 125-131.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| neuronal calcium sensor 1 | Golgi-localized isozyme PI4KIIIbeta can be activated by protein kinase D phosphorylation, and also through interactions with neuronal calcium sensor 1 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | some anti-viral molecules are isoform selective phosphatidylinositol 4-kinase inhibitors. Isozymes PI4KIIalpha and PI4KIIbeta are wortmannin-insensitive | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | isozyme PI4KIIbeta | Homo sapiens | 5829 | - |
| endoplasmic reticulum | isozyme PI4KIIIalpha | Homo sapiens | 5783 | - |
| Golgi apparatus | isozyme PI4KIIIbeta is recruited to and principally localizes to the Golgi complex through GTP-bound Arf1 binding | Homo sapiens | 5794 | - |
| vesicle | intracellular, isozyme PI4KIIbeta | Homo sapiens | 31982 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Homo sapiens |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55000 | - |
isozymes PI4KIIalpha or PI4KIIbeta | Homo sapiens |
| 91000 | - |
isozyme PI4KIIIbeta | Homo sapiens |
| 230000 | - |
isozyme PI4KIIIalpha | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
four isozymes PI4KIIIalpha and PI4KIIIbeta, and PI4KIIalpha and PI4KIIbeta | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | isozyme PI4KIIIbeta can be activated by protein kinase D phosphorylation | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bladder transitional cell carcinoma cell | - |
Homo sapiens | - |
| breast cancer cell | non-specific infiltrating duct and infiltrating lobular carcinomas | Homo sapiens | - |
| carcinoma cell | isozyme PI4KIIalpha expression is upregulated in many human cancers but is especially highly expressed in malignant melanoma, fibrosarcoma, breast cancer (non-specific infiltrating duct and infiltrating lobular carcinomas) bladder transitional cell carcinoma and thyroid papillary carcinoma | Homo sapiens | - |
| fibrosarcoma cell | - |
Homo sapiens | - |
| liver | isozyme PI4KIIbeta is strongly expressed in the liver | Homo sapiens | - |
| melanoma cell | - |
Homo sapiens | - |
| papillary thyroid carcinoma cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 1-phosphatidyl-1D-myo-inositol | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha type II PI 4-kinase | - |
Homo sapiens |
| beta type II PI 4-kinase | - |
Homo sapiens |
| phosphatidylinositol 4-kinase | - |
Homo sapiens |
| PI4KIIalpha | - |
Homo sapiens |
| PI4KIIbeta | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | alterations to phosphatidylinositol 4-kinase expression levels can modulate MAP kinase and Akt signalling, and are important for chemoresistance, tumour angiogenesis and the suppression of apoptosis and metastases | Homo sapiens |
| physiological function | PI4KIIIbeta localised to the Golgi complex through GTP-bound Arf1 binding, can be activated by protein kinase D phosphorylation, and also through interactions with neuronal calcium sensor 1. 1-Phosphatidyl-1D-myo-inositol 4-phosphate PI4P is an essential phospholipid substrate for two phosphoinositide-dependent signalling pathways that control cell migration and proliferation. It induces expression of Girdin in several cancers, and its translocation to the plasma membrane where it activates heterotrimeric Gai proteins to stimulate PI(3,4,5)P3 synthesis by PI 3-kinase, overview. The enzyme shows a potential role for a plasma membrane pool of PI4P in regulating Girdin targeting and EGFR signalling. PI4KIIIa may have an underappreciated function in the constitutive chemoresistance of cancers which are recalcitrant to apoptotic induction. PI4KIIbeta isoform migh exhibit an anti-metastatic role in hepatocellular carcinoma | Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
