Literature summary for 2.7.1.67 extracted from

Burgess, J.; Del Bel, L.M.; Ma, C.I.; Barylko, B.; Polevoy, G.; Rollins, J.; Albanesi, J.P.; Kraemer, H.; Brill, J.A.
Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila (2012), Development, 139, 3040-3050.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
endosome	dynamic tubular, PI4KII	Drosophila melanogaster	5768	-
Golgi apparatus	PI4KII	Drosophila melanogaster	5794	-
additional information	PI4KII localizes to the Golgi and to a dynamic tubular endosomal network	Drosophila melanogaster	-	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required	Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 1-phosphatidyl-1D-myo-inositol	Drosophila melanogaster	-	ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
salivary gland	-	Drosophila melanogaster	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 1-phosphatidyl-1D-myo-inositol	-	Drosophila melanogaster	ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
PI4KII	-	Drosophila melanogaster
type II phosphatidylinositol 4-kinase	-	Drosophila melanogaster

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Drosophila melanogaster

General Information

General Information	Comment	Organism
malfunction	in PI4KII mutants, mucin-containing glue granules fail to reach normal size, with glue protein aberrantly accumulating in enlarged Rab7-positive late endosomes. PI4KIIDELTA mutants reveal small glue granules of grossly normal morphology, PI4KIIDELTA cells also exhibited large vacuolated structures not observed in wild-type, phenotype, overview. Retromer localization and dynamics are altered in PI4KIIDELTA mutants	Drosophila melanogaster
metabolism	formation of PI4KII-containing endosomal tubules is independent of retromer or AP-3 function, but retromer dynamics at LEs depends on PI4KII	Drosophila melanogaster
physiological function	phosphatidylinositol 4-phosphate is a key regulator of membrane trafficking. Specific requirement for PI4KII emerged in larval salivary glands. In the Golgi, PI4KII is required for sorting of glue granule cargo and the granule-associated SNARE Snap24. In endosomes, it is required for normal retromer dynamics and for formation of tubular endosomes that are likely to be involved in retrieving Snap24 and lysosomal enzyme receptor protein from late endosomes to the trans-Golgi network. PI4KII in flies thus reveals a role for PI4KII in regulating the fidelity of granule protein trafficking in secretory tissues, PI4KII catalytic activity is required for granule biogenesis and normal endosome size, overview	Drosophila melanogaster

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Release 2023.1 (January 2023)