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Literature summary for 2.7.1.67 extracted from

  • Cappell, S.D.; Dohlman, H.G.
    Selective regulation of MAP kinase signaling by an endomembrane phosphatidylinositol 4-kinase (2011), J. Biol. Chem., 286, 14852-14860.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus isozyme Pik1 Saccharomyces cerevisiae 5794
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Golgi membrane isozyme Pik1 Saccharomyces cerevisiae 139
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membrane isozyme Pik1 Saccharomyces cerevisiae 16020
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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-
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Synonyms

Synonyms Comment Organism
phosphatidylinositol 4-kinase
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 Saccharomyces cerevisiae
Pik1
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 Saccharomyces cerevisiae

General Information

General Information Comment Organism
malfunction depletion of PIK1 results in a subsequent loss of intracellular 1-phosphatidyl-1D-myo-inositol 4-phosphate, and loss of Pik1 induces elongated growth, because knockdown of PIK1 results in the constitutive activation of Kss1, which subsequently drives elongated growth Saccharomyces cerevisiae
physiological function Pik1, a phosphatidylinositol 4-kinase that localizes primarily to the Golgi, is required for proper pheromone signaling acting independently of Ste5, overview. It also regulates MAP kinase specificity but does so independently of Ste5. Pik1 is required for full activation of the MAP kinases Fus3 and Hog1 and represses activation of Kss1. Pik1 likely regulates Ste11 and Ste50, components shared by all three MAP kinase pathways, through their interaction with the scaffold protein Opy2. Pik1 acts as a regulator of signaling specificity functioning at endomembranes rather than at the plasma membrane. Pik1 is required for full Fus3 activation and inhibits Kss1 activation. Pik1 acts via Ste11 or a pathway component downstream of Ste11, overview Saccharomyces cerevisiae