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Literature summary for 2.7.1.67 extracted from

  • Tai, A.W.; Salloum, S.
    The role of the phosphatidylinositol 4-kinase PI4KA in hepatitis C virus-induced host membrane rearrangement (2011), PLoS ONE, 6, e26300.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.67

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of N-terminal myc-tagged PI4KB and 3xFLAG-tagged PI4KA in Huh7.5.1 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
D1899A mutant of isozyme PI4KA Homo sapiens
additional information Huh7.5.1 cells are transduced with a nontargeting lentiviral shRNA construct or shRNA constructs targeting PI4KA or PI4KB. Expression of shRNA-resistant wild-type PI4KA rescues HCV replication in OR6 cells silenced for endogenous PI4KA, while the kinase-dead PI4KA D1899A mutant cannot rescue viral replication in OR6 cells silenced for endogenous PI4KA Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PI4KB does not interact with NS5A in hepatitis C virus-infected cells ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyes PI4KA and PI4KB
-

Source Tissue

Source Tissue Comment Organism Textmining
Huh-7.5.1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PI4KB does not interact with NS5A in hepatitis C virus-infected cells Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
phosphatidylinositol 4-kinase
-
 Homo sapiens
PI4KA
-
 Homo sapiens
PI4KB
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction silencing of the PI 4-kinase PI4KA leads to abberrant membranous web morphology, and PI4KB silencing inhibits HCV infection, overview. PI4KA silencing-induced membrane clustering depends on HCV polyprotein cleavage but does not require integrity of the endoplasmic reticulum-Golgi secretory pathway Homo sapiens
additional information PI4KA interacts with viral protein NS5A in hepatitis C virus-infected cells Homo sapiens
physiological function isozyme PI4KA plays an essential role in hepatitis C virus membranous webs formation and colocalizes with the hepatitis C virus membranous webs, which show phosphatidylinositol 4-phosphate enrichment, while isozyme PI4KB supports the HCV life cycle but does not localize to or generate phosphatidylinositol 4-phosphate at membranous webs Homo sapiens