Activating Compound | Comment | Organism | Structure |
---|---|---|---|
advanced glycation end products | may stimulate PIP5Kgamma to increase 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate production, which may enhance adaptor protein complex 2 localisation to clathrin pits, increase clathrin pit formation, enhance renal Na+/K+ ATPase cargo recognition by adaptor protein complex 2 and/or stimulate cytosolic phospholipase A2 alpha activity | Homo sapiens | |
advanced glycation end products | may stimulate PIP5Kgamma to increase 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate production, which may enhance adaptor protein complex 2 localisation to clathrin pits, increase clathrin pit formation, enhance renal Na+/K+ ATPase cargo recognition by adaptor protein complex 2 and/or stimulate cytosolic phospholipase A2 alpha activity | Sus scrofa |
Protein Variants | Comment | Organism |
---|---|---|
additional information | PIP5Kgamma isozyme knockout by siRNA. Transfection of HK2 cells with PIP5Kgamma siRNA prevents advanced glycation end products-bovine serum albumin inhibition of renal Na+/K+ ATPase activity | Homo sapiens |
additional information | PIP5Kgamma isozyme knockout by siRNA. Transfection of HK2 cells with PIP5Kgamma siRNA prevents advanced glycation end products-bovine serum albumin inhibition of renal Na+/K+ ATPase activity | Sus scrofa |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens | |
Mg2+ | required | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | Homo sapiens | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | Sus scrofa | - |
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | - |
Homo sapiens | - |
HK-2 cell | - |
Homo sapiens | - |
LLC-PK1 cell | - |
Sus scrofa | - |
proximale tubular epithelium | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
Homo sapiens | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? | |
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate | - |
Sus scrofa | ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
phosphatidylinositol 4-phosphate 5-kinase gamma | - |
Homo sapiens |
phosphatidylinositol 4-phosphate 5-kinase gamma | - |
Sus scrofa |
PIP5Kgamma | - |
Homo sapiens |
PIP5Kgamma | - |
Sus scrofa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Sus scrofa |
General Information | Comment | Organism |
---|---|---|
physiological function | phosphatidylinositol 4,5 bisphosphate is a major membrane phospholipid that affects cellular processes such as actin cytoskeleton modulation, membrane trafficking and ion channel activity. Isozyme PIP5Kgamma is essential for advanced glycation end products induced inhibition of renal Na+/K+ ATPase activity | Homo sapiens |
physiological function | phosphatidylinositol 4,5 bisphosphate is a major membrane phospholipid that affects cellular processes such as actin cytoskeleton modulation, membrane trafficking and ion channel activity. Isozyme PIP5Kgamma is essential for advanced glycation end products induced inhibition of renal Na+/K+ ATPase activity | Sus scrofa |