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Literature summary for 2.7.1.72 extracted from

  • Walker, J.B.
    ATP:streptomycin 6-phosphotransferase (1975), Methods Enzymol., 43, 628-632.
    View publication on PubMed

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Streptomyces bikiniensis
Mg2+ required Streptomyces glebosus
Mn2+ can replace Mg2+ in activation Streptomyces bikiniensis
Mn2+ can replace Mg2+ in activation Streptomyces glebosus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + streptomycin Streptomyces glebosus
-
ADP + streptomycin 6-phosphate
-
?
ATP + streptomycin Streptomyces bikiniensis detoxification of a potent inhibitor of protein biosynthesis ADP + streptomycin 6-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Streptomyces bikiniensis
-
-
-
Streptomyces glebosus
-
strain ATCC 14607
-

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
Streptomyces bikiniensis
-
mycelium
-
Streptomyces glebosus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
assay methods Streptomyces bikiniensis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3'-deoxydihydrostreptomycin + ATP
-
Streptomyces bikiniensis ADP + 3'-deoxydihydrostreptomycin 6-phosphate
-
?
ATP + dihydrostreptomycin
-
Streptomyces bikiniensis ADP + dihydrostreptomycin 6-phosphate
-
?
ATP + dihydrostreptomycin
-
Streptomyces glebosus ADP + dihydrostreptomycin 6-phosphate
-
?
ATP + streptomycin
-
Streptomyces bikiniensis ADP + streptomycin 6-phosphate
-
?
ATP + streptomycin
-
Streptomyces glebosus ADP + streptomycin 6-phosphate
-
?
ATP + streptomycin detoxification of a potent inhibitor of protein biosynthesis Streptomyces bikiniensis ADP + streptomycin 6-phosphate
-
?
dATP + streptomycin
-
Streptomyces bikiniensis dADP + streptomycin 6-phosphate
-
?
dihydrostreptomycin 3''-alpha-phosphate + ATP
-
Streptomyces bikiniensis ADP + dihydrostreptomycin 3''-alpha-phosphate 6-phosphate
-
?
dihydrostreptomycin 3''-phosphate + ATP
-
Streptomyces bikiniensis ADP + dihydrostreptomycin 3'',6-bisphosphate
-
?
streptidine + ATP
-
Streptomyces bikiniensis streptidine 6-phosphate + ADP O-phosphorylstreptidine + ADP ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
35
-
assay at Streptomyces bikiniensis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
-
Streptomyces bikiniensis
7.4
-
-
Streptomyces glebosus
7.4
-
assay at Streptomyces bikiniensis
7.4
-
assay at Streptomyces glebosus
9
-
assay at, method 1 Streptomyces bikiniensis

Cofactor

Cofactor Comment Organism Structure
ATP
-
Streptomyces bikiniensis
ATP
-
Streptomyces glebosus