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Literature summary for 2.7.1.74 extracted from

  • Shewach, D.S.; Reynolds, K.K.; Hertel, L.
    Nucleotide specificity of human deoxycytidine kinase (1992), Mol. Pharmacol., 42, 518-524.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
dCTP no inhibition at physiological concentrations Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukemia cell leukemic T-lymphoblasts Homo sapiens
-
leukemia cell cell line MOLT-4 Homo sapiens
-
MOLT-4 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NTP + 2',2'-difluoro-2'-deoxycytidine best acceptor substrate, best phosphate donors: UTP or NTP-mixture, better than ATP Homo sapiens NDP + 2',2'-difluoro-2'-deoxycytidine 5'-phosphate
-
?
NTP + 9-beta-D-arabinofuranosyl-2-fluoroadenine
-
Homo sapiens NDP + 9-beta-D-arabinofuranosyl-2-fluoroadenine 5'-phosphate
-
?
NTP + cytosine arabinoside D-isomer Homo sapiens NDP + cytosine arabinoside 5'-monophosphate
-
?
NTP + cytosine arabinoside best phosphate donors: UTP or NTP-mixture, even better than ATP Homo sapiens NDP + cytosine arabinoside 5'-monophosphate
-
?
NTP + deoxycytidine enzyme shows little specificity towards phosphate donor Homo sapiens NDP + dCMP
-
?
UTP + 2'-deoxycytidine as good as CTP, GTP or dATP Homo sapiens UDP + 2'-deoxy-CMP
-
?