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Literature summary for 2.7.1.74 extracted from

  • Hubeek, I.; Peters, G.J.; Broekhuizen, A.J.F.; Talianidis, I.; Schouten van Meeteren, A.Y.N.; van Wering, E.R.; Gibson, B.; Creutzig, U.; Kaspers, G.J.L.
    Immunocytochemical detection of deoxycytidine kinase in pediatric malignancies in relation to in vitro cytarabine sensitivity (2004), Nucleosides Nucleotides Nucleic Acids, 23, 1351-1356.
    View publication on PubMed
Search for more literature for 2.7.1.74

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 2'-deoxycytidine Homo sapiens
-
 ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
ATP + cytarabine Homo sapiens drug against acute myeloid and lymphoblastic leukemia ADP + cytarabine 5'-phosphate
-
 ?
additional information Homo sapiens resistance of cells to cytarabine is caused by dCK enzyme deficiency ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain tumor cell low enzyme expression level Homo sapiens
-
additional information high enzyme expression level in case of acute myeloid leukemia and acute lymphoblastic leukemia, sensitivity of cell types to cytarabine, overview Homo sapiens
-
retinoblastoma cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 MTT assay method Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2'-deoxycytidine
-
 Homo sapiens ADP + 2'-deoxycytidine 5'-phosphate
-
 ?
ATP + cytarabine drug against acute myeloid and lymphoblastic leukemia Homo sapiens ADP + cytarabine 5'-phosphate
-
 ?
ATP + cytarabine i.e. 1-beta-D-arabinofuranosylcytosine Homo sapiens ADP + cytarabine 5'-phosphate
-
 ?
additional information resistance of cells to cytarabine is caused by dCK enzyme deficiency Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
dCK
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens