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Literature summary for 2.7.1.74 extracted from

  • Szatmari, T.; Huszty, G.; Desaknai, S.; Spasokoukotskaja, T.; Sasvari-Szekely, M.; Staub, M.; Esik, O.; Safrany, G.; Lumniczky, K.
    Adenoviral vector transduction of the human deoxycytidine kinase gene enhances the cytotoxic and radiosensitizing effect of gemcitabine on experimental gliomas (2008), Cancer Gene Ther., 15, 154-164.
    View publication on PubMed

Application

Application Comment Organism
medicine deoxycytidine kinase overexpression substantially increases both the toxic and radiosensitizing effects of gemcitabine. Enhancement is mild in murine GI261 cells and much stronger in rat C6 and human U373 cells. Combination of enzyme overexpression, gemcitabine treatment and irradiation improves the survival rate of C6 cell bearing rats significantly Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in murine GI261, rat C6 and human U373 cell Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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