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Literature summary for 2.7.1.74 extracted from

  • Hellendahl, K.; Kamel, S.; Wetterwald, A.; Neubauer, P.; Wagner, A.
    Human deoxycytidine kinase is a valuable biocatalyst for the synthesis of nucleotide analogues (2019), Catalysts, 9, 997 .
No PubMed abstract available
Search for more literature for 2.7.1.74

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 cells Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 10 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NTP + deoxycytidine Homo sapiens
-
 NDP + dCMP
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P27707
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + fludarabine 53% conversion Homo sapiens ADP + fludarabine 5'-phosphate
-
 ?
GTP + arabinosyl-adenine
-
 Homo sapiens GDP + arabinosyl-adenine 5'-phosphate
-
 ?
GTP + azacytidine
-
 Homo sapiens GDP + azacytidine 5'-phosphate
-
 ?
GTP + cladribine
-
 Homo sapiens GDP + cladribine 5'-phosphate
-
 ?
GTP + clofarabine
-
 Homo sapiens GDP + clofarabine 5'-phosphate
-
 ?
GTP + fludarabine 54% conversion Homo sapiens GDP + fludarabine 5'-phosphate
-
 ?
GTP + gemcitabine
-
 Homo sapiens GDP + gemcitabine 5'-phosphate
-
 ?
GTP + lamivudine
-
 Homo sapiens GDP + lamivudine 5'-phosphate
-
 ?
additional information the enzyme shows no activity with zidovudine, stavudine, iodoxuridine, thymidine and deoxyuridine Homo sapiens ?
-
-
NTP + deoxycytidine
-
 Homo sapiens NDP + dCMP
-
 ?
UTP + fludarabine 13% conversion Homo sapiens UDP + fludarabine 5'-phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 34500, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
dCK
-
 Homo sapiens