Literature summary for 2.7.1.78 extracted from

Mani, R.S.; Karimi-Busheri, F.; Fanta, M.; Cass, C.E.; Weinfeld, M.
Spectroscopic studies of DNA and ATP binding to human polynucleotide kinase: evidence for a ternary complex (2003), Biochemistry, 42, 12077-12084.

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Inhibitors

Inhibitors	Comment	Organism	Structure
beta,gamma-imidoadenosine 5'-triphosphate	binds with high affinity, similar to ATP	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
57102	-	1 * 58000, SDS-PAGE, 1 * 57102, calculated	Homo sapiens
58000	-	sedimentation equilibrium analysis	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	bifunctional enzyme with both 5-DNA kinase and 3-DNA phosphatase activity	-

Reaction

Reaction	Comment	Organism	Reaction ID
ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA	mechanism involves a ternary complex of enzyme, ATP and DNA	Homo sapiens	a

Subunits

Subunits	Comment	Organism
monomer	1 * 58000, SDS-PAGE, 1 * 57102, calculated	Homo sapiens

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Release 2023.1 (January 2023)