Literature summary for 2.7.1.91 extracted from

Kono, K.; Sugiura, M.; Kohama, T.
Inhibition of recombinant sphingosine kinases by novel inhibitors of microbial origin, F-12509A and B-5354c (2002), J. Antibiot., 55, 99-103.

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Inhibitors

Inhibitors	Comment	Organism	Structure
B-5354c	SPHK1, SPHK2, noncompetitive to sphingosine	Homo sapiens
F-12509A	SPHK1, SPHK2, competitive to sphingosine	Homo sapiens
N,N-dimethylsphingosine	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	recombinant SPHK1, SPHK2	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0022	-	B-5354c	SPHK2	Homo sapiens
0.003	-	N,N-dimethylsphingosine	SPHK1	Homo sapiens
0.004	-	F-12509A	SPHK1	Homo sapiens
0.004	-	B-5354c	SPHK1	Homo sapiens
0.0055	-	F-12509A	SPHK2	Homo sapiens
0.0086	-	N,N-dimethylsphingosine	SPHK2	Homo sapiens

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Release 2023.1 (January 2023)