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Literature summary for 2.7.1.91 extracted from
- Calcium mobilization via sphingosine kinase in signalling by the FceRI antigen receptor (1996), Nature, 380, 634-636.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| DL-threo-dihydrosphingosine | competitive | Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + sphinganine | Rattus norvegicus | calcium mobilization through antigen receptors utilizes enzyme | ADP + sphinganine 1-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
mast-cell line RBL-2H3 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + sphinganine | calcium mobilization through antigen receptors utilizes enzyme | Rattus norvegicus | ADP + sphinganine 1-phosphate | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.005 | 0.018 | D,L-threo-dihydrosphingosine | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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