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Literature summary for 2.7.1.91 extracted from
- Sphingosine kinase activity is required for sphingosine-mediated phospholipase D activation in C2C12 myoblasts (2004), Biochem. J., 381, 655-663.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| transient expression in murine C2C12 myoblasts in the cytosolic fraction, in Golgi-enriched and endosome/plasma membrane fraction of transfected cells, the over-expressed SphK1 is localized at plasma membrane, as well as at internal membranes, SphK1 partially colocalized with caveolin-1, known to be an integral plasma membrane protein, secretion of extracellularly produced sphingosine 1-phosphate | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
| Golgi apparatus | - |
Homo sapiens | 5794 | - |
| membrane | - |
Homo sapiens | 16020 | - |
| plasma membrane | - |
Homo sapiens | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + sphingosine | Homo sapiens | sphingosine is a modulator of membrane signal transduction systems and a regulatory element of cardiac and skeletal muscle physiology | ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a intracellular messenger molecule and ann extracellular ligand for specific membrane receptors | ? |  |
| additional information | Homo sapiens | sphingosine and sphingosine 1-phosphate activate phospholipase D in mouse myoblasts | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isozyme SphK1 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + sphingosine | - |
Homo sapiens | ADP + sphingosine 1-phosphate | - |
? | |
| ATP + sphingosine | sphingosine is a modulator of membrane signal transduction systems and a regulatory element of cardiac and skeletal muscle physiology | Homo sapiens | ADP + sphingosine 1-phosphate | sphingosine 1-phosphate is a intracellular messenger molecule and ann extracellular ligand for specific membrane receptors | ? | |
| additional information | sphingosine and sphingosine 1-phosphate activate phospholipase D in mouse myoblasts | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| sphinganine kinase | - |
Homo sapiens |
| SPHK | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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