Literature summary for 2.7.1.91 extracted from

Kim, J.W.; Kim, Y.W.; Inagaki, Y.; Hwang, Y.A.; Mitsutake, S.; Ryu, Y.W.; Lee, W.K.; Ha, H.J.; Park, C.S.; Igarashi, Y.
Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases (2005), Bioorg. Med. Chem., 13, 3475-3485.

Search for more literature for 2.7.1.91

Cloned(Commentary)

Cloned (Comment)	Organism
transient expression of HA-tagged isozymes SphK1 and SphK2 in CHO-K1 cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
(2R)-2-amino-4-(4-octylphenyl)butan-1-ol	i.e. (R)-2-amino-4-(4-octylphenyl)butan-1-ol, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2	Homo sapiens
(2R,3S)-3-amino-4-morpholin-4-yl-1-phenylbutan-2-ol	i.e. (2R,3S)-3-amino-4-morpholino-1-phenylbutan-2-ol, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2	Homo sapiens
(2S,3R)-2-amino-4-(4-octylphenyl)butane-1,3-diol	i.e. (2S,3R)-2-amino-4-(4-octylphenyl)butane-1,3-diol, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2	Homo sapiens
(2S,3S)-2-amino-4-(4-octylphenyl)butane-1,3-diol	i.e. (2S,3S)-2-amino-4-(4-octylphenyl)butane-1,3-diol, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2	Homo sapiens
additional information	inhibitors of isozyme SphK2 are cytotoxic, overview, inhibitory potency of the synthetic sphingosine analogues on isozymes SphK1 and SphK2, overview	Homo sapiens
N,N-dimethylsphingosine	inhibition of isozymes SphK1 and SphK2	Homo sapiens
N-((2S,3S)-1,3-dihydroxy-4-phenylbutan-2-yl)tridecanamide	i.e. N-((2S,3S)-1,3-dihydroxy-4-phenylbutan-2-yl)tridecanamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2	Homo sapiens
N-[(1R)-1-(hydroxymethyl)-3-phenylpropyl]tridecanamide	i.e. N-((R)-1-hydroxy-4-phenylbutan-2-yl)tridecanamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2	Homo sapiens
N-[(1R)-3-phenyl-1-(pyrrolidin-1-ylmethyl)propyl]decanamide	i.e. N-((R)-4-phenyl-1-(pyrrolidin-1-yl)butan-2-yl)decanamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2	Homo sapiens
N-[(1S)-1-methyl-3-phenylpropyl]hexadecanamide	i.e. N-((R)-1-hydroxy-4-phenylbutan-2-yl)palmitamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2	Homo sapiens
N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-3-phenylpropyl]hexadecanamide	i.e. N-((2S,3R)-1,3-dihydroxy-4-phenylbutan-2-yl)palmitamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2	Homo sapiens
N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)-3-phenylpropyl]tridecanamide	i.e. N-((2S,3R)-1,3-dihydroxy-4-phenylbutan-2-yl)tridecanamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2	Homo sapiens
N-[(1S,2R)-2-hydroxy-3-phenyl-1-(pyrrolidin-1-ylmethyl)propyl]octadecanamide	i.e. N-((2S,3R)-3-hydroxy-4-phenyl-1-(pyrrolidin-1-yl)butan-2-yl)stearamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2	Homo sapiens
N-[(1S,2S)-2-hydroxy-1-(hydroxymethyl)-3-phenylpropyl]hexadecanamide	i.e. N-((2S,3S)-1,3-dihydroxy-4-phenylbutan-2-yl)palmitamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2	Homo sapiens
N-[(1S,2S)-2-hydroxy-1-(morpholin-4-ylmethyl)-3-phenylpropyl]decanamide	i.e. N-((2S,3S)-3-hydroxy-1-morpholino-4-phenylbutan-2-yl)decanamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2	Homo sapiens
N-[(1S,2S)-2-hydroxy-3-phenyl-1-(pyrrolidin-1-ylmethyl)propyl]decanamide	i.e. N-((2S,3S)-3-hydroxy-4-phenyl-1-(pyrrolidin-1-yl)butan-2-yl)decanamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2	Homo sapiens
N-[(1S,2S)-2-hydroxy-3-phenyl-1-(pyrrolidin-1-ylmethyl)propyl]octadecanamide	i.e. N-((2S,3S)-3-hydroxy-4-phenyl-1-(pyrrolidin-1-yl)butan-2-yl)stearamide, synthetic sphingosine analogue, specific inhibition of isozymes SphK1 and SphK2	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + sphingosine	Homo sapiens	-	ADP + sphingosine 1-phosphate	sphingosine 1-phosphate is a mediator in diverse biological processes such as cell differentiation, proliferation, motility, and apoptosis	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isozymes SphK1 and SphK2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
platelet	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + phytosphingosine	low activity	Homo sapiens	ADP + phytosphingosine 1-phosphate	-	?
ATP + sphingosine	-	Homo sapiens	ADP + sphingosine 1-phosphate	-	?
ATP + sphingosine	-	Homo sapiens	ADP + sphingosine 1-phosphate	sphingosine 1-phosphate is a mediator in diverse biological processes such as cell differentiation, proliferation, motility, and apoptosis	?
additional information	FYT720 is no substrate of isozymes SphK1 and SphK2	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
sphinganine kinase	-	Homo sapiens
SPHK	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)