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Literature summary for 2.7.1.91 extracted from

  • Kihara, A.; Anada, Y.; Igarashi, Y.
    Mouse sphingosine kinase isoforms SPHK1a and SPHK1b differ in enzymatic traits including stability, localization, modification, and oligomerization (2006), J. Biol. Chem., 281, 4532-4539.
    View publication on PubMed
Search for more literature for 2.7.1.91

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK -293T cells and embryonal carcinoma cells Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information site-directed mutagenesis at Cys-4 and Cys-5 residues results in increased sphingosine kinase activity Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
34000
-
 SDS-PAGE Mus musculus
43000
-
 SDS-PAGE Mus musculus
43300
-
 calculated from sequence of cDNA Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus Q8CI15
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
heart
-
 Mus musculus
-
kidney
-
 Mus musculus
-
liver
-
 Mus musculus
-
lung
-
 Mus musculus
-
skeletal muscle
-
 Mus musculus
-
spleen
-
 Mus musculus
-
testis
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + sphingosine
-
 Mus musculus ADP + sphingosine 1-phosphate
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 43000, SDS-PAGE Mus musculus
oligomer
-
 Mus musculus

Synonyms

Synonyms Comment Organism
sphingosine kinase type 1
-
 Mus musculus
SPHK1a stable enzyme form Mus musculus
SPHK1b unstable enzyme form Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus