Literature summary for 2.7.1.91 extracted from

Nishiuma, T.; Nishimura, Y.; Okada, T.; Kuramoto, E.; Kotani, Y.; Jahangeer, S.; Nakamura, S.
Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model (2008), Am. J. Physiol. Lung Cell. Mol. Physiol., 294, L1085-L1093.

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Application

Application	Comment	Organism
medicine	targeting SPHK may provide a novel therapeutic tool to treat bronchial asthma	Mus musculus

Inhibitors

Inhibitors	Comment	Organism	Structure
2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole	the inhibition of SPHK affects acute eosinophilic inflammation induced in antigen-challenged mouse model	Mus musculus
N,N-dimethylsphingosine	the inhibition of SPHK affects acute eosinophilic inflammation induced in antigen-challenged mouse model	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Synonyms

Synonyms	Comment	Organism
sphinganine kinase	-	Mus musculus
SPHK	-	Mus musculus

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Release 2023.1 (January 2023)