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Literature summary for 2.7.1.91 extracted from
- Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart (2007), J. Biochem. Mol. Toxicol., 21, 273-279.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| N,N-dimethylsphingosine | 0.005 mM, activation to 106% of control | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D,L-threo-dihydrosphingosine | 0.005 mM, 64% inhibition | Rattus norvegicus | |
| DL-threo-dihydrosphingosine | 0.005 mM, 25% inhibition | Rattus norvegicus | |
| FTY720 | 0.005 mM, 73% inhibition; 0.005 mM, 8% inhibition | Rattus norvegicus | |
| L-erythro-sphingosine | 0.005 mM, 41% inhibition; 0.005 mM, 43% inhibition | Rattus norvegicus | |
| N,N-dimethylsphingosine | 0.005 mM, 56% inhibition | Rattus norvegicus | |
| phytosphingosine | 0.0025 mM, 21% inhibition; 0.0025 mM, 64% inhibition | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45000 | - |
x * 45000, SDS-PAGE | Rattus norvegicus |
| 96000 | - |
x * 96000, SDS-PAGE | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | Q6AYB2 | - |
- |
| Rattus norvegicus | Q91V26 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + sphingosine | - |
Rattus norvegicus | ADP + sphingosine 1-phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 45000, SDS-PAGE | Rattus norvegicus |
| ? | x * 96000, SDS-PAGE | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SK1 | - |
Rattus norvegicus |
| SK2 | - |
Rattus norvegicus |
| sphinganine kinase | - |
Rattus norvegicus |
| SPHK1 | - |
Rattus norvegicus |
| SPHK2 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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