Literature summary for 2.7.1.91 extracted from

Martin, C.; Lafosse, J.M.; Malavaud, B.; Cuvillier, O.
Sphingosine kinase-1 mediates androgen-induced osteoblast cell growth (2009), Biochem. Biophys. Res. Commun., 391, 669-673.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MC3T3-E1 cell	mouse calvaria osteoblast cell	Mus musculus	-

Expression

Organism	Comment	Expression
Mus musculus	dihydrotestosterone triggers cell growth in steroid-deprived MC-3T3 cells, associated with a rapid stimulation of isoform SphK1 and activation of both Akt and ERK signaling pathways. This mechanism relies on functional androgen receptor/PI3K/Akt nongenotropic signaling as pharmacological antagonists can block SphK1 stimulation by dihydrotestosterone and its consequences. SphK1 inhibition also blocks cell proliferation, while ERK inhibition has no impact	up

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Release 2023.1 (January 2023)