Literature summary for 2.7.1.91 extracted from

Yan, G.; Chen, S.; You, B.; Sun, J.
Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids (2008), Cardiovasc. Res., 78, 308-314.

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Activating Compound

Activating Compound	Comment	Organism	Structure
11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid	treatment markedly augments SK activity in HUVECs. At the concentration of 1 mM, 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid increases SK activity by 110% and the maximal effect on SK activation is observed at 20 min after 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid addition. Inhibition of SK by a specific inhibitor, SKI-II, markedly attenuates 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid-induced endothelial cell proliferation. 11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid-induced activation of Akt kinase and transactivation of the epidermal growth factor receptor are also inhibited by SKI-II	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
G82D	dominant-negative SK1mutant, displays substantially attenuated 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid-induced endothelial cell proliferation, migration, and tube formation in vitro and Matrigel plug angiogenesis in vivo	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
SKI-II	isoform Sk1-specific inhibitor. Treatment markedly attenuates 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid-induced endothelial cell proliferation. 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoic acid-induced activation of Akt kinase and transactivation of the epidermal growth factor receptor are also inhibited by SKI-II	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HUVEC cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	knockdown of SK1 expression by specific siRNA inhibits 11,12-epoxyeicosatrienoic acid-induced endothelial cell proliferation and migration, whereas SK2 siRNA knockdown is without effect	Homo sapiens

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Release 2023.1 (January 2023)