Literature summary for 2.7.1.91 extracted from

Li, J.; Guan, H.Y.; Gong, L.Y.; Song, L.B.; Zhang, N.; Wu, J.; Yuan, J.; Zheng, Y.J.; Huang, Z.S.; Li, M.
Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival (2008), Clin. Cancer Res., 14, 6996-7003.

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Application

Application	Comment	Organism
medicine	SPHK1in astrocytoma cell lines is elevated at both mRNA and protein levels, and the SPHK1 mRNA and protein are significantly up-regulated by up to 6.8- and 40fold, respectively, in primary astrocytomas compared with those in the adjacent noncancerous brain tissues. 41.2% of paraffin-embedded archival astrocytoma biopsies exhibit high expression of SPHK1. The up-regulation of SPHK1 is significantly correlated with the histologic grade of astrocytoma and patients with high SPHK1 level exhibit shorter survival time	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-172 cell	-	Homo sapiens	-
LN-235 cell	-	Homo sapiens	-
LN-382 cell	-	Homo sapiens	-
LN-444 cell	-	Homo sapiens	-
LN-464 cell	-	Homo sapiens	-
SNB-19 cell	-	Homo sapiens	-
T-98G cell	-	Homo sapiens	-
U-87MG cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)