Literature summary for 2.7.1.91 extracted from

Hong, J.H.; Youm, J.K.; Kwon, M.J.; Park, B.D.; Lee, Y.M.; Lee, S.I.; Shin, D.M.; Lee, S.H.
K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular Ca2+ signaling (2008), J. Invest. Dermatol., 128, 2166-2178.

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Activating Compound

Activating Compound	Comment	Organism	Structure
N-(1,3-dihydroxyisopropyl)-2-hexyl-3-oxo-decanamide	i.e. K6PC-5, activates SphK in a dose-dependent manner. K6PC-5 induces mobilization in hairless mouse epidermis. Both dimethylsphingosine and dihydroxysphingosine, SphK inhibitors, and transfection of SphK1-siRNA blocks K6PC-5-induced increases in intracellular Ca2+ concentration	Mus musculus
N-(1,3-dihydroxyisopropyl)-2-hexyl-3-oxo-decanamide	i.e. K6PC-5, induces intracellular Ca2+ concentration oscillations in HaCaT cells. The K6PC-5-induced intracellular Ca2+ oscillations are dependent on thapsigargin-sensitive Ca2+ stores and Ca2+ entry, but independent of the classical phospholipase C-mediated pathway. K6PC-5 enhances the expression of involucrin and filaggrin, specific differentiation-associated marker proteins in HaCaT cells, whereas transfection of SphK1 siRNA blocks the increase of involucrin	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood	-	Mus musculus	-
epidermis	-	Mus musculus	-
F9-12 cell	-	Mus musculus	-
HaCaT cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)