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Literature summary for 2.7.1.91 extracted from

  • Pchejetski, D.; Doumerc, N.; Golzio, M.; Naymark, M.; Teissie, J.; Kohama, T.; Waxman, J.; Malavaud, B.; Cuvillier, O.
    Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models (2008), Mol. Cancer Ther., 7, 1836-1845.
    View publication on PubMed

Application

Application Comment Organism
medicine pharmacologic SphK1 inhibition with B-5354c sensitizes LNCaP and PC-3 cells to docetaxel and camptothecin, respectively. In vivo, camptothecin and B-5354c alone display a limited effect on tumor growth in PC-3 cells, whereas in combination there is a synergy of effect on tumor size with a significant increase in the ceramide to sphingosine 1-phosphate sphingolipid ratio Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
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Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
B-5354c SphK1 inhibitor, induces apoptosis in a caspase-dependent manner by tilting the ceramide/sphingosine 1-phosphate rheostat toward ceramide. Pharmacologic SphK1 inhibition with B-5354c sensitizes LNCaP and PC-3 cells to docetaxel and camptothecin, respectively. In vivo, camptothecin and B-5354c alone display a limited effect on tumor growth in PC-3 cells, whereas in combination there is a synergy of effect on tumor size with a significant increase in the ceramide to sphingosine 1-phosphate sphingolipid ratio Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
LNCaP cell
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Homo sapiens
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PC-3 cell
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Homo sapiens
-

General Information

General Information Comment Organism
physiological function SphK1 enforced expression in PC-3 and LNCaP cells shifts the lipid biostat toward prosurvival sphingosine 1-phosphate and protects against B-5354c–induced apoptosis Homo sapiens