Activating Compound | Comment | Organism | Structure |
---|---|---|---|
heregulin | heregulin stimulates SphK1 activity only in filamin A-expressing A7 melanoma cells but not in filamin A-deficient cells and induces its translocation and colocalization with filamin A at lamellipodia. SphK1 is required for heregulin-induced migration, lamellipodia formation, activation of PAK1, and subsequent filamin A phosphorylation. Sphingosine 1-phosphate directly stimulates PAK1 kinase. Heregulin also induces colocalization of S1P1, the promotility sphingosine 1-phosphate receptor, but not S1P2, with SphK1 and filamin A at membrane ruffles | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in HEK-293 cell | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A7 cell | - |
Homo sapiens | - |
melanoma cell line | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | filamin A links SphK1 and S1P1 receptor to locally influence the dynamics of actin cytoskeletal structures by orchestrating the concerted actions of of SphK1, FLNa, and PAK1, each of which requires and/or regulates the actions of the others, at lamellipodia to promote cell movement | Homo sapiens |