Literature summary for 2.7.1.91 extracted from

Nayak, D.; Huo, Y.; Kwang, W.X.; Pushparaj, P.N.; Kumar, S.D.; Ling, E.A.; Dheen, S.T.
Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia (2009), Neuroscience, 166, 132-144.

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Inhibitors

Inhibitors	Comment	Organism	Structure
N,N-dimethylsphingosine	suppression of SphK1 by its inhibitor, N,N-dimethylsphingosine, or siRNA results in decreased mRNA expression of TNF-alpha, IL-1beta and iNOS and release of TNF-alpha and nitric oxide in lipopolysaccharid-activated microglia	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
BV-2 cell	-	Mus musculus	-

Expression

Organism	Comment	Expression
Mus musculus	treatment with lipopolysaccharide increases the SphK1 mRNA and protein expression in microglia leading to altered expression and production of proinflammatory cytokines and nitric oxide. Suppression of SphK1 by its inhibitor, N, N-dimethylsphingosine, or siRNA results in decreased mRNA expression of TNF-alpha, IL-1beta and iNOS and release of TNF-alpha and nitric oxide in lipopolysaccharid-activated microglia	up

General Information

General Information	Comment	Organism
physiological function	suppression of SphK1 by its inhibitor, N,N-dimethylsphingosine, or siRNA results in decreased mRNA expression of TNF-alpha, IL-1beta and iNOS and release of TNF-alpha and nitric oxide in lipopolysaccharid-activated microglia	Mus musculus

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Release 2023.1 (January 2023)