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Literature summary for 2.7.11.25 extracted from
- Molecular cloning, characterization and functional analysis of a putative mitogen-activated protein kinase kinase kinase 4 (MEKK4) from blood clam Tegillarca granosa (2017), Fish Shellfish Immunol., 66, 372-381 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| GADD45 protein | - |
Tegillarca granosa |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HEK-293T cells | Tegillarca granosa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + ERK1 | Tegillarca granosa | - |
ADP + phosphorylated ERK1 | - |
? |  |
| ATP + ERK2 | Tegillarca granosa | - |
ADP + phosphorylated ERK2 | - |
? | |
| ATP + JNK1 | Tegillarca granosa | - |
ADP + phosphorylated JNK1 | - |
? | |
| ATP + JNK2 | Tegillarca granosa | - |
ADP + phosphorylated JNK2 | - |
? | |
| ATP + MKK3 | Tegillarca granosa | - |
ADP + phosphorylated MKK3 | - |
? | |
| ATP + MKK4 | Tegillarca granosa | - |
ADP + phosphorylated MKK4 | - |
? | |
| ATP + MKK6 | Tegillarca granosa | - |
ADP + phosphorylated MKK6 | - |
? | |
| ATP + MKK7 | Tegillarca granosa | - |
ADP + phosphorylated MKK7 | - |
? | |
| ATP + p38 | Tegillarca granosa | - |
ADP + phosphorylated p38 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Tegillarca granosa | A0A1X9RHQ4 | blood clam | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adductor | high expression | Tegillarca granosa | - |
| foot | lowest expression | Tegillarca granosa | - |
| gill | highest expression | Tegillarca granosa | - |
| hemocyte | - |
Tegillarca granosa | - |
| mantle | - |
Tegillarca granosa | - |
| visceral mass | - |
Tegillarca granosa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + ERK1 | - |
Tegillarca granosa | ADP + phosphorylated ERK1 | - |
? | |
| ATP + ERK2 | - |
Tegillarca granosa | ADP + phosphorylated ERK2 | - |
? | |
| ATP + JNK1 | - |
Tegillarca granosa | ADP + phosphorylated JNK1 | - |
? | |
| ATP + JNK2 | - |
Tegillarca granosa | ADP + phosphorylated JNK2 | - |
? | |
| ATP + MKK3 | - |
Tegillarca granosa | ADP + phosphorylated MKK3 | - |
? | |
| ATP + MKK4 | - |
Tegillarca granosa | ADP + phosphorylated MKK4 | - |
? | |
| ATP + MKK6 | - |
Tegillarca granosa | ADP + phosphorylated MKK6 | - |
? | |
| ATP + MKK7 | - |
Tegillarca granosa | ADP + phosphorylated MKK7 | - |
? | |
| ATP + p38 | - |
Tegillarca granosa | ADP + phosphorylated p38 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 41220, calculated from amino acid sequence | Tegillarca granosa |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MAP3K4 | - |
Tegillarca granosa |
| MEKKK4 | - |
Tegillarca granosa |
| mitogen-activated protein kinase kinase kinase 4 | - |
Tegillarca granosa |
| MTK1 | - |
Tegillarca granosa |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Tegillarca granosa | calculated from amino acid sequence | - |
6.3 |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Tegillarca granosa | the mRNA expression of isoform MEKK4 is up-regulated significantly in hemocytes after infection with lipopolysaccharide (3.4fold after 24 h), Vibrio parahaemolyticus (3.2fold after 6 h) or Vibrio alginolyticus (2.5fold after 12 h) | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | isoform MEKK4 is involved in innate immune response of blood clam | Tegillarca granosa |
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