Application | Comment | Organism |
---|---|---|
medicine | inhibition of the enzyme can provide a method of treatment for cardiovascular and respiratory disorders, construction of possible specific fluoro-phosphonate inhibitors | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
overexpression in Saccharomyces cerevisiae | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,3-bis(difluoro)-1,3-diphospho-2-dihydroxypropane | phosphonate analogues of 1,3-diphosphoglycerate | Saccharomyces cerevisiae | |
1,4-bis(difluoro)-1,4-diphospho-diethylether | phosphonate analogues of 1,3-diphosphoglycerate | Saccharomyces cerevisiae | |
additional information | - |
Homo sapiens | |
additional information | inhibitory effect of phosphonate analogues of 1,3-diphosphoglycerate, overview | Saccharomyces cerevisiae |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens | |
Mg2+ | - |
Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 3-phospho-D-glycerate | - |
Homo sapiens | ADP + 1,3-diphosphoglycerate | - |
r | |
ATP + 3-phospho-D-glycerate | - |
Saccharomyces cerevisiae | ADP + 1,3-diphosphoglycerate | - |
r |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
7.5 | - |
assay at | Saccharomyces cerevisiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ADP | - |
Homo sapiens | |
ADP | - |
Saccharomyces cerevisiae | |
ATP | true substrate is the magnesium complexes of ATP | Homo sapiens | |
ATP | true substrate is the magnesium complexes of ATP | Saccharomyces cerevisiae | |
ATP | required as phosphate donor | Homo sapiens | |
ATP | required as phosphate donor | Saccharomyces cerevisiae |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Ki-values for phosphonate analogues of 1,3-diphosphoglycerate | Saccharomyces cerevisiae | |
1.44 | 1.5 | 1,3-bis(difluoro)-1,3-diphospho-2-dihydroxypropane | pH 7.5, 25°C | Saccharomyces cerevisiae | |
3.25 | 3.3 | 1,4-bis(difluoro)-1,4-diphospho-diethylether | pH 7.5, 25°C | Saccharomyces cerevisiae |