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Literature summary for 2.7.2.3 extracted from

  • Kovari, Z.; Flachner, B.; Naray-Szabo, G.; Vas, M.
    Crystallographic and thiol-reactivity studies on the complex of pig muscle phosphoglycerate kinase with ATP analogues: correlation between nucleotide binding mode and helix flexibility (2002), Biochemistry, 41, 8796-8806.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme in ternary complex with Mg2+-bound ATP analogue inhibitors Mg-beta,gamma-methylene-adenosine-5'-triphosphate and Mg-beta,gamma-imido-adenosine-5'-triphosphate, and substrate 3-phospho-D-glycerate, hanging drop vapour diffusion method, reservoir solution: 10 mM beta,gamma-methylene-adenosine-5'-triphosphate, 12 mM MgCl2, 10 mM 3-phospho-D-glycerate, 27-28% w/w polyethylene glycol 8000, pH 7.0, 15°C, a few weeks, X-ray structure determination and analysis Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoic acid) nucleotide ligands protect, e.g. MgATP2-, MgADP-, Mg-beta,gamma-methylene-adenosine-5'-triphosphate, Mg-beta,gamma-imido-adenosine-5'-triphosphate Sus scrofa
beta,gamma-imido-adenosine-5'-triphosphate binding structure; i.e. AMP-PNP, an ATP analogue Sus scrofa
beta,gamma-methylene-adenosine-5'-triphosphate binding structure; i.e. AMP-PCP, an ATP analogue Sus scrofa
iodoacetamide nucleotide ligands protect, e.g. MgATP2-, MgADP-, Mg-beta,gamma-methylene-adenosine-5'-triphosphate, Mg-beta,gamma-imido-adenosine-5'-triphosphate Sus scrofa
Mg-beta,gamma-imido-adenosine-5'-triphosphate
-
Sus scrofa
Mg-beta,gamma-methylene-adenosine-5'-triphosphate
-
Sus scrofa
MgADP-
-
Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa Q7SIB7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 3-phospho-D-glycerate
-
Sus scrofa ADP + 1,3-diphosphoglycerate
-
r

Cofactor

Cofactor Comment Organism Structure
ADP
-
Sus scrofa
ATP required as phosphate donor Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.039
-
MgADP- pH 7.5, 20°C Sus scrofa
0.58
-
Mg-beta,gamma-imido-adenosine-5'-triphosphate pH 7.5, 20°C Sus scrofa
1.21
-
Mg-beta,gamma-methylene-adenosine-5'-triphosphate pH 7.5, 20°C Sus scrofa