Application | Comment | Organism |
---|---|---|
medicine | PGK1 may serve as prognostic marker and/or be a potential therapeutic target to prevent dissemination of gastric carcinoma cells into the peritoneum | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
into plasmid vector pEF-IRES, overexpressed in MKN-45 cells | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | patients with peritoneal carcinomatosis show a medium to strong nuclear staining for PGK1 | Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gastric adenocarcinoma cell line | - |
Homo sapiens | - |
MKN-45 cell | distinct expression of PGK1 | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PGK1 | - |
Homo sapiens |
phosphoglycerate kinase 1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | considerable downregulation of PGK1 expression in siPGK1-treated cells compared to control cells | down |
Homo sapiens | CXCR4 regulates the expression of PGK1. Overexpression of PGK1 in patients with development of peritoneal carcinomatosis | up |
General Information | Comment | Organism |
---|---|---|
physiological function | PGK1 regulates the expression of CXCR4 and beta-catenin at the mRNA and protein levels. PGK1 and CXCR4 regulate their expression reciprocally. Overexpression of PGK1 dramatically increases the invasiveness of gastric cancer cells. Inhibition of CXCR4 in cells overexpressing PGK1 produces only a moderate reduction of invasiveness suggesting that, PGK1 itself has a critical role in tumor invasiveness. PGK1 may be a crucial enzyme in peritoneal dissemination, enhanced expression of PGK1 and its signaling targets CXCR4 and beta-catenin in gastric cancer cells promote peritoneal carcinomatosis | Homo sapiens |