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Literature summary for 2.7.2.3 extracted from

  • Xu, M.; McCarrey, J.R.; Hecht, N.B.
    A cytoplasmic variant of the KH-type splicing regulatory protein serves as a decay-promoting factor for phosphoglycerate kinase 2 mRNA in murine male germ cells (2008), Nucleic Acids Res., 36, 7157-7167.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.2.3

Inhibitors

Inhibitors Comment Organism Structure
additional information the KH-type splicing regulatory protein, KSRP, serves as a decay-promoting factor for Pgk2 mRNA in male germ cells. KSRP binds to to a 93-nt sequence (the F1 region) of the 3'-UTR of the Pgk2 mRNA and destabilizes Pgk2 mRNA constructs in testis extracts and in transfected cells. Destabilization of Pgk2 mRNA occurs when t-KSRP and the Pgk2 mRNA-stabilizing protein, polypyrimidine tract binding protein 2 (PTBP2), are present together in complexes bound to the 3'-UTR of Pgk2 mRNA Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-
nucleus
-
 Mus musculus 5634
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
germ cell Pgk2 mRNA accumulates in postmeiotic germ cells Mus musculus
-
spermatid
-
 Mus musculus
-
spermatocyte in early meiosis Mus musculus
-
testis similar levels of Pgk2 mRNA transcription in nuclei isolated from the testes of prepuberal (17 day old) and adult mice Mus musculus
-

Synonyms

Synonyms Comment Organism
PGK2
-
 Mus musculus
phosphoglycerate kinase 2
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus in the cytoplasm of early meiotic spermatocytes, t-KSRP promotes the decay of Pgk2 mRNA down
Mus musculus Pgk2 mRNA is first detectable in early meiosis in spermatocytes and increases dramatically in spermatids. Decline of t-KSRP in late meiosis and increase of PTBP2 are concomitant with the increase in Pgk2 mRNA levels up