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Literature summary for 2.7.2.6 extracted from

  • Sly, W.S.; Stadtman, E.R.
    Formate metabolsim. II Enzymatic synthesis of formyl phosphate and formal coenzyme A in Clostridium cylindrosporum (1963), J. Biol. Chem., 238, 2639-2647.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
p-mercuribenzoate formate kinase I and II Clostridium cylindrosporum
p-mercuriphenylsulfonic acid
-
Clostridium cylindrosporum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
400
-
formate formate kinase I, ATP + formate + hydroxylamine Clostridium cylindrosporum

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ formate kinase I: activates, formate kinase II: 80% as effective as Mn2+ in activation, Km: 2.5 mM Clostridium cylindrosporum
Mn2+ formate kinase I: can partially replace Mg2+ in activation, formate kinase II: activates, Km: 0.5 mM Clostridium cylindrosporum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + formate Clostridium cylindrosporum the product formyl phosphate serves as formyl donor for the synthesis of formyl coenzyme A in a reaction catalyzed by phosphate acetyltransferase ADP + formyl phosphate
-
?

Organism

Organism UniProt Comment Textmining
Clostridium cylindrosporum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial, formate kinase I and formate kinase II Clostridium cylindrosporum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetate formate kinase II Clostridium cylindrosporum ADP + acetyl phosphate
-
?
ATP + formate formate kinase I: reaction is not easily, if at all, reversible, reaction catalyzed by formate kinase II is freely reversible Clostridium cylindrosporum ADP + formyl phosphate
-
r
ATP + formate the product formyl phosphate serves as formyl donor for the synthesis of formyl coenzyme A in a reaction catalyzed by phosphate acetyltransferase Clostridium cylindrosporum ADP + formyl phosphate
-
?
ATP + propionate formate kinase II Clostridium cylindrosporum ADP + propionyl phosphate
-
?
CTP + formate formate kinase I: less than 5% as effective as ATP, formate kinase II: 30% as effective as ATP Clostridium cylindrosporum CDP + formyl phosphate
-
r
GTP + formate formate kinase I: 20% as effective as ATP, formate kinase II: nearly as effective as ATP Clostridium cylindrosporum GDP + formyl phosphate
-
r
ITP + formate formate kinase I: less than 5% as effective as ATP, formate kinase II: 60% as effective as ATP Clostridium cylindrosporum IDP + formyl phosphate
-
r
UTP + formate formate kinase I: less than 5% as effective as ATP, formate kinase II: 50% as effective as ATP Clostridium cylindrosporum UDP + formyl phosphate
-
r

Synonyms

Synonyms Comment Organism
More formate kinase II may be identical with acetate kinase Clostridium cylindrosporum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8 6.9 formate kinase I Clostridium cylindrosporum
7.2
-
formate kinase II Clostridium cylindrosporum