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Literature summary for 2.7.3.2 extracted from

  • Hoshino, F.; Murakami, C.; Sakai, H.; Satoh, M.; Sakane, F.
    Creatine kinase muscle type specifically interacts with saturated fatty acid- and/or monounsaturated fatty acid-containing phosphatidic acids (2019), Biochem. Biophys. Res. Commun., 513, 1035-1040 .
    View publication on PubMed
Search for more literature for 2.7.3.2

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Rosetta 2 (DE3) cells Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 30 mM used in assay conditions Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + phosphocreatine Mus musculus
-
 ATP + creatine
-
 r
ATP + creatine Mus musculus
-
 ADP + phosphocreatine
-
 ?
ATP + creatine Mus musculus
-
 ADP + phosphocreatine
-
 r

Organism

Organism UniProt Comment Textmining
Mus musculus P07310
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphocreatine
-
 Mus musculus ATP + creatine
-
 r
ATP + creatine
-
 Mus musculus ADP + phosphocreatine
-
 ?
ATP + creatine
-
 Mus musculus ADP + phosphocreatine
-
 r
additional information the enzyme binds to 1,2-dipalmitoyl-sn-glycero-3-phosphate with the highest affinity (dissociation constant: 0.002 mM) Mus musculus ?
-
-
additional information the enzyme binds to 1,2-dipalmitoyl-snglycero-3-phosphate with the highest affinity (dissociation constant 0.002 mM). The enzyme preferentially interacts with saturated fatty acid- and/or monounsaturated fatty acid-containing phosphatidic acids, but not with polyunsaturated fatty acid-containing phosphatidic acids Mus musculus ?
-
-

Subunits

Subunits Comment Organism
? x * 44000, His6-tagged enzyme, SDS-PAGE Mus musculus
? x * 43000, His6-tagged enzyme, SDS-PAGE Mus musculus
? x * 43264, calculated from amino acid sequence Mus musculus

Synonyms

Synonyms Comment Organism
CKM
-
 Mus musculus
creatine kinase muscle type
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
metabolism the enzyme preferentially interacts with saturated fatty acid- and/or monounsaturated fatty acid-containing phosphatidic acids, but not with polyunsaturated fatty acid-containing phosphatidic acids. Notably, the enzyme exclusively interacts with phosphatidic acid, whereas the protein does not bind to other lipids such as diacylglycerol, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, phosphatidylinositol (3,4,5)-triphosphate and cardiolipin Mus musculus