Literature summary for 2.7.4.1 extracted from

Parks, Q.M.; Hobden, J.A.
Polyphosphate kinase 1 and the ocular virulence of Pseudomonas aeruginosa (2005), Invest. Ophthalmol. Vis. Sci., 46, 248-251.

Search for more literature for 2.7.4.1

Cloned(Commentary)

Cloned (Comment)	Organism
complementation of the PPK1-deficient mutant strain PAOM5 by the wild-type PPK1	Pseudomonas aeruginosa

Protein Variants

Protein Variants	Comment	Organism
additional information	the PPK1-deficient strain PAOM5, an isogenic mutant of strain PAO1, is significantly less virulent than either wild-type strain PAO1 or the complemented mutant, the loss of ocular virulence is probably due to the dysregulation of multiple genes, including those responsible for stress response, the PPK1-deficient mutant produces significantly less pyocyanin, phenotype, overview	Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + (phosphate)n	Pseudomonas aeruginosa	PPK1 is essential for a successful ocular infection by the organism	ADP + (phosphate)n+1	-	?

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	cultured in mouse eyes	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + (phosphate)n	-	Pseudomonas aeruginosa	ADP + (phosphate)n+1	-	?
ATP + (phosphate)n	PPK1 is essential for a successful ocular infection by the organism	Pseudomonas aeruginosa	ADP + (phosphate)n+1	-	?

Synonyms

Synonyms	Comment	Organism
polyphosphate kinase 1	-	Pseudomonas aeruginosa
PPK1	-	Pseudomonas aeruginosa

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)