Literature summary for 2.7.4.1 extracted from

Gautam, L.K.; Sharma, P.; Capalash, N.
Bacterial polyphosphate kinases revisited role in pathogenesis and therapeutic potential (2019), Curr. Drug Targets, 20, 292-301 .

Organism

Organism	UniProt	Comment	Textmining
Bacillus cereus	-	-	-
Escherichia coli	-	-	-
Escherichia coli K1 (RS218)	-	-	-
Francisella tularensis	-	-	-
Helicobacter pylori	-	-	-
Neisseria meningitidis	-	-	-
Porphyromonas gingivalis	-	-	-
Proteus mirabilis	-	-	-
Pseudomonas aeruginosa	-	-	-
Salmonella enterica subsp. enterica serovar Typhimurium	-	-	-

Synonyms

Synonyms	Comment	Organism
PPK	-	Salmonella enterica subsp. enterica serovar Typhimurium
PPK	-	Proteus mirabilis
PPK	-	Porphyromonas gingivalis
PPK1	-	Escherichia coli
PPK1	-	Pseudomonas aeruginosa
PPK1	-	Neisseria meningitidis
PPK1	-	Helicobacter pylori
PPK2	-	Pseudomonas aeruginosa
PPK2	-	Francisella tularensis

General Information

General Information	Comment	Organism
drug target	the absence of a polyphosphate kinase orthologue in humans makes it a potential drug target	Salmonella enterica subsp. enterica serovar Typhimurium
drug target	the absence of a polyphosphate kinase orthologue in humans makes it a potential drug target	Escherichia coli
drug target	the absence of a polyphosphate kinase orthologue in humans makes it a potential drug target	Pseudomonas aeruginosa
drug target	the absence of a polyphosphate kinase orthologue in humans makes it a potential drug target	Neisseria meningitidis
drug target	the absence of a polyphosphate kinase orthologue in humans makes it a potential drug target	Bacillus cereus
drug target	the absence of a polyphosphate kinase orthologue in humans makes it a potential drug target	Proteus mirabilis
drug target	the absence of a polyphosphate kinase orthologue in humans makes it a potential drug target	Helicobacter pylori
drug target	the absence of a polyphosphate kinase orthologue in humans makes it a potential drug target	Porphyromonas gingivalis
drug target	the absence of a polyphosphate kinase orthologue in humans makes it a potential drug target	Francisella tularensis
malfunction	polyphosphate kinase deletion causes decreased resistance to oxidative, heat and hyperosmotic stress, attenuated swarming and biofilm formation, increased production of prolyl isomerase, phosphotransferase and peptidoglycan synthase repressor proteins	Proteus mirabilis
malfunction	polyphosphate kinase deletion causes decreased virulence and low invasiveness	Salmonella enterica subsp. enterica serovar Typhimurium
malfunction	polyphosphate kinase deletion causes loss of biofilm formation on polyvinyl chloride (PVC) or borosilicate	Porphyromonas gingivalis
malfunction	polyphosphate kinase deletion decreases sporulation, motility and biofilm formation	Bacillus cereus
malfunction	polyphosphate kinase deletion increases sensitivity to H2O2 and reduces polyphosphate accumulation. Polyphosphate kinase deletion upregulates fermentation, aerobic and anaerobic respiration, enhances catalase and Clp protease activity, down-regulates ATP-dependent RNA helicase, DNA polymerase III and pyruvate kinase I	Escherichia coli
malfunction	polyphosphate kinase ppk1 deletion causes loss of virulence and biofilm formation, impaired motility and increased susceptibility to antibiotics. Polyphosphate kinase ppk2 deletion causes increased susceptibility to antibiotics	Pseudomonas aeruginosa
malfunction	polyphosphate kinase ppk1 deletion causes low polyphosphate accumulation, loss of virulence, reduced colonization in mice and decreased motility	Helicobacter pylori
malfunction	polyphosphate kinase ppk1 deletion causes poor survival during osmotic shock and acid challenge	Escherichia coli
malfunction	polyphosphate kinase ppk1 deletion increases serum sensitivity	Neisseria meningitidis
malfunction	polyphosphate kinase ppk2 deletion causes increased sensitivity to antibiotics	Francisella tularensis
physiological function	the enzyme has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics	Salmonella enterica subsp. enterica serovar Typhimurium
physiological function	the enzyme has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics	Escherichia coli
physiological function	the enzyme has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics	Pseudomonas aeruginosa
physiological function	the enzyme has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics	Neisseria meningitidis
physiological function	the enzyme has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics	Bacillus cereus
physiological function	the enzyme has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics	Proteus mirabilis
physiological function	the enzyme has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics	Helicobacter pylori
physiological function	the enzyme has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics	Porphyromonas gingivalis
physiological function	the enzyme has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics	Francisella tularensis