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Literature summary for 2.7.4.14 extracted from

  • Alexandre, J.A.; Roy, B.; Topalis, D.; Pochet, S.; Perigaud, C.; Deville-Bonne, D.
    Enantioselectivity of human AMP, dTMP and UMP-CMP kinases (2007), Nucleic Acids Res., 35, 4895-4904.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.4.14

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
L-CMP excess of L-CMP Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
 D-CMP
-
 Homo sapiens
0.05
-
 D-UMP
-
 Homo sapiens
0.15
-
 L-3TCMP
-
 Homo sapiens
0.36
-
 beta-D-2'-azido-2'-dCMP
-
 Homo sapiens
0.7
-
 L-dUMP L-enantiomers have lower reaction rates Homo sapiens
0.73
-
 L-dCMP L-enantiomers have lower reaction rates Homo sapiens
0.75
-
 L-CMP
-
 Homo sapiens
0.9
-
 beta-D-2'-azido-2'-dUMP
-
 Homo sapiens
1
-
 D-dCMP
-
 Homo sapiens
1.2
-
 beta-L-2'-azido-2'-dCMP
-
 Homo sapiens
1.3
-
 D-dUMP
-
 Homo sapiens
1.3
-
 beta-L-2'-azido-2'-dUMP
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P30085
-
-

Purification (Commentary)

Purification (Comment) Organism
of the recombinant proteins Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-D-2'-azido-2'-dCMP
-
 Homo sapiens ADP + beta-D-2'-azido-2'-dCDP
-
 ?
ATP + beta-D-2'-azido-2'-dUMP
-
 Homo sapiens ADP + beta-D-2'-azido-2'-dUDP
-
 ?
ATP + beta-L-2'-azido-2'-dCMP
-
 Homo sapiens ADP + beta-L-2'-azido-2'-dCDP
-
 ?
ATP + beta-L-2'-azido-2'-dUMP
-
 Homo sapiens ADP + beta-L-2'-azido-2'-dUDP
-
 ?
ATP + D-CMP
-
 Homo sapiens ADP + D-CDP
-
 ?
ATP + D-dCMP
-
 Homo sapiens ADP + D-dCDP
-
 ?
ATP + D-dUMP
-
 Homo sapiens ADP + D-dUDP
-
 ?
ATP + D-UMP
-
 Homo sapiens ADP + D-UDP
-
 ?
ATP + L-3TCMP
-
 Homo sapiens ADP + L-3TCMP
-
 ?
ATP + L-CMP poor substrate Homo sapiens ADP + L-CDP
-
 ?
ATP + L-dCMP slower phosphorylation than the D-enantiomers Homo sapiens ADP + L-dCDP
-
 ?
ATP + L-dUMP slower phosphorylation than the D-enantiomers Homo sapiens ADP + L-dUDP
-
 ?

Synonyms

Synonyms Comment Organism
cytidylate kinase
-
 Homo sapiens
UCK
-
 Homo sapiens
UMP-CMP kinase
-
 Homo sapiens