KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.02 | - |
D-CMP | pH 7.4, 37°C | Homo sapiens | |
0.05 | - |
D-UMP | pH 7.4, 37°C | Homo sapiens | |
0.36 | - |
2'-azido-D-dCMP | pH 7.4, 37°C | Homo sapiens | |
0.7 | - |
L-dUMP | pH 7.4, 37°C | Homo sapiens | |
0.73 | - |
L-dCMP | pH 7.4, 37°C | Homo sapiens | |
0.75 | - |
L-CMP | pH 7.4, 37°C | Homo sapiens | |
0.9 | - |
2'-azido-D-dUMP | pH 7.4, 37°C | Homo sapiens | |
1 | - |
D-dCMP | pH 7.4, 37°C | Homo sapiens | |
1.2 | - |
2'-azido-L-dCMP | pH 7.4, 37°C | Homo sapiens | |
1.3 | - |
D-dUMP | pH 7.4, 37°C | Homo sapiens | |
1.3 | - |
2'-azido-L-dUMP | pH 7.4, 37°C | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + CMP | Homo sapiens | - |
ADP + CDP | - |
? | |
ATP + dCMP | Homo sapiens | higher activity with the D-enantiomer compared to the L-enantiomer | ADP + dCDP | - |
? | |
ATP + dUMP | Homo sapiens | higher activity with the D-enantiomer compared to the L-enantiomer | ADP + dUDP | - |
? | |
ATP + UMP | Homo sapiens | - |
ADP + UDP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 2'-azido-CMP | 4fold higher activity with 2'-azido-dCMP than with 2'-azido-CMP | Homo sapiens | ADP + 2'-azido-CDP | - |
? | |
ATP + 2'-azido-D-dCMP | - |
Homo sapiens | ADP + 2'-azido-D-dCDP | - |
? | |
ATP + 2'-azido-D-dUMP | - |
Homo sapiens | ADP + 2'-azido-D-dUDP | - |
? | |
ATP + 2'-azido-dCMP | 4fold higher activity with 2'-azido-dCMP than with 2'-azido-CMP | Homo sapiens | ADP + 2'-azido-dCDP | - |
? | |
ATP + 2'-azido-dUMP | similar activity with 2'-azido-UMP and 2'-azido-dUMP | Homo sapiens | ADP + 2'-azido-dUDP | - |
? | |
ATP + 2'-azido-L-dCMP | - |
Homo sapiens | ADP + 2'-azido-L-dCDP | - |
? | |
ATP + 2'-azido-L-dUMP | - |
Homo sapiens | ADP + 2'-azido-L-dUDP | - |
? | |
ATP + 2'-azido-UMP | similar activity with 2'-azido-UMP and 2'-azido-dUMP | Homo sapiens | ADP + 2'-azido-UDP | - |
? | |
ATP + CMP | - |
Homo sapiens | ADP + CDP | - |
? | |
ATP + dCMP | higher activity with the D-enantiomer compared to the L-enantiomer | Homo sapiens | ADP + dCDP | - |
? | |
ATP + dUMP | higher activity with the D-enantiomer compared to the L-enantiomer | Homo sapiens | ADP + dUDP | - |
? | |
ATP + L-CMP | - |
Homo sapiens | ADP + L-CDP | - |
? | |
ATP + L-dCMP | - |
Homo sapiens | ADP + L-dCDP | - |
? | |
ATP + L-dUMP | - |
Homo sapiens | ADP + L-dUDP | - |
? | |
ATP + UMP | - |
Homo sapiens | ADP + UDP | - |
? | |
additional information | the enzyme shows enantioselectivity, acceptor-binding site structure of human UMP-CMP kinase in the closed form or in ligand-bound forms, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
nucleoside monophosphate kinase | - |
Homo sapiens |
UMP-CMP kinase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |