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BRENDA support

Literature summary for 2.7.4.2 extracted from

  • Schirra, F.; Richards, S.M.; Sullivan, D.A.
    Androgen influence on cholesterogenic enzyme mRNA levels in the mouse meibomian gland (2007), Curr. Eye Res., 32, 393-398.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
testosterone treatment of meibomian gland stimulates a significant increase in the mRNA levels of mevalonate kinase, phosphomevalonate kinase, mevalonate diphosphate decarboxylase, isopentenyl diphosphate isomerase, geranylgeranyl diphosphate synthase, squalene epoxidase, lanosterol synthase, lanosterol demethylase, and DELTA7-sterol reductase Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
meibomian gland from castrated mice. Treatment with androgens may promote cholesterol biosynthesis Mus musculus
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