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Literature summary for 2.7.4.21 extracted from

  • Prasad, A.; Jia, Y.; Chakraborty, A.; Li, Y.; Jain, S.K.; Zhong, J.; Roy, S.G.; Loison, F.; Mondal, S.; Sakai, J.; Blanchard, C.; Snyder, S.H.; Luo, H.R.
    Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling (2011), Nat. Immunol., 12, 752-760.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.4.21

Inhibitors

Inhibitors Comment Organism Structure
N(2)-(m-(trifluoromethyl)benzyl) N(6)-(p-nitrobenzyl)purine selective inhibitor in vitro Homo sapiens
N(2)-(m-(trifluoromethyl)benzyl) N(6)-(p-nitrobenzyl)purine selective inhibitor in vitro Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Mus musculus
-
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1D-myo-inositol hexakisphosphate
-
 Mus musculus ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate
-
 ?
ATP + 1D-myo-inositol hexakisphosphate
-
 Homo sapiens ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)-pentakisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
inositol hexakisphosphate kinase 1
-
 Mus musculus
inositol hexakisphosphate kinase 1
-
 Homo sapiens
InsP6K1
-
 Mus musculus
InsP6K1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction isoform InsP6K1 disruption augments phosphatidylinositol-(3,4,5)-trisphosphate signaling and enhances superoxide production in neutrophils Mus musculus
malfunction isoform InsP6K1 disruption augments phosphatidylinositol-(3,4,5)-trisphosphate signaling and enhances superoxide production in neutrophils Homo sapiens
physiological function inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling. The enzyme does not regulate neutrophil trafficking and survival Mus musculus
physiological function inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling. The enzyme does not regulate neutrophil trafficking and survival Homo sapiens