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Literature summary for 2.7.4.3 extracted from
- Adenylate kinase (1973), The Enzymes,3rd Ed. (Boyer,P. D. ,ed. ), 8, 279-305.
No PubMed abstract available
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| muscle | Homo sapiens |
| muscle | Sus scrofa |
| muscle | Oryctolagus cuniculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5,5'-dithiobis(2-nitrobenzoic acid) | not: liver enzyme | Bos taurus |  |
| 5,5'-dithiobis(2-nitrobenzoic acid) | - |
Escherichia coli | |
| 5,5'-dithiobis(2-nitrobenzoic acid) | muscle enzyme | Homo sapiens | |
| 5,5'-dithiobis(2-nitrobenzoic acid) | not: liver enzyme | Rattus norvegicus | |
| 5,5'-dithiobis(2-nitrobenzoic acid) | - |
Saccharomyces cerevisiae | |
| 5,5'-dithiobis(2-nitrobenzoic acid) | - |
Sus scrofa | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetic constants of adenylate kinases from various sources | Homo sapiens | |
| additional information | - |
additional information | kinetic constants of adenylate kinases from various sources | Rattus norvegicus | |
| additional information | - |
additional information | kinetic constants of adenylate kinases from various sources | Saccharomyces cerevisiae | |
| additional information | - |
additional information | kinetic constants of adenylate kinases from various sources | Bos taurus | |
| additional information | - |
additional information | kinetic constants of adenylate kinases from various sources | Oryctolagus cuniculus | |
| additional information | - |
additional information | kinetic constants of adenylate kinases from various sources | Blattidae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Bacillus subtilis | 5829 | - |
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Escherichia coli | 5829 | - |
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Sus scrofa | 5829 | - |
| cytosol | - |
Saccharomyces cerevisiae | 5829 | - |
| cytosol | - |
Bos taurus | 5829 | - |
| cytosol | - |
Triticum aestivum | 5829 | - |
| cytosol | - |
Oryctolagus cuniculus | 5829 | - |
| cytosol | - |
Physarum polycephalum | 5829 | - |
| cytosol | - |
Thiobacillus denitrificans | 5829 | - |
| cytosol | - |
Citrus limon | 5829 | - |
| cytosol | - |
Blattidae | 5829 | - |
| cytosol | isozyme II | Rattus norvegicus | 5829 | - |
| mitochondrion | intermembrane space | Homo sapiens | 5739 | - |
| mitochondrion | intermembrane space | Rattus norvegicus | 5739 | - |
| mitochondrion | intermembrane space | Sus scrofa | 5739 | - |
| mitochondrion | intermembrane space | Bos taurus | 5739 | - |
| mitochondrion | intermembrane space | Oryctolagus cuniculus | 5739 | - |
| mitochondrion | intermembrane space | Blattidae | 5739 | - |
| additional information | - |
Bacillus subtilis | - |
- |
| additional information | - |
Mus musculus | - |
- |
| additional information | - |
Escherichia coli | - |
- |
| additional information | - |
Homo sapiens | - |
- |
| additional information | - |
Sus scrofa | - |
- |
| additional information | - |
Saccharomyces cerevisiae | - |
- |
| additional information | - |
Bos taurus | - |
- |
| additional information | - |
Triticum aestivum | - |
- |
| additional information | - |
Oryctolagus cuniculus | - |
- |
| additional information | - |
Physarum polycephalum | - |
- |
| additional information | - |
Thiobacillus denitrificans | - |
- |
| additional information | - |
Citrus limon | - |
- |
| additional information | - |
Blattidae | - |
- |
| additional information | particle-associated | Rattus norvegicus | - |
- |
| additional information | subcellular distribution of 4 rat isozymes | Rattus norvegicus | - |
- |
| nucleus | - |
Homo sapiens | 5634 | - |
| nucleus | - |
Rattus norvegicus | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ba2+ | requirement | Saccharomyces cerevisiae | |
| Ba2+ | requirement | Oryctolagus cuniculus | |
| Ba2+ | in decreasing order of efficiency: Mg2+, Ca2+, Mn2+, Ba2+ | Saccharomyces cerevisiae | |
| Ba2+ | in decreasing order of efficiency: Mg2+, Ca2+, Mn2+, Ba2+ | Oryctolagus cuniculus | |
| Ba2+ | forms complex with di- or trinucleotide | Bacillus subtilis | |
| Ba2+ | forms complex with di- or trinucleotide | Mus musculus | |
| Ba2+ | forms complex with di- or trinucleotide | Escherichia coli | |
| Ba2+ | forms complex with di- or trinucleotide | Homo sapiens | |
| Ba2+ | forms complex with di- or trinucleotide | Rattus norvegicus | |
| Ba2+ | forms complex with di- or trinucleotide | Sus scrofa | |
| Ba2+ | forms complex with di- or trinucleotide | Saccharomyces cerevisiae | |
| Ba2+ | forms complex with di- or trinucleotide | Bos taurus | |
| Ba2+ | forms complex with di- or trinucleotide | Triticum aestivum | |
| Ba2+ | forms complex with di- or trinucleotide | Oryctolagus cuniculus | |
| Ba2+ | forms complex with di- or trinucleotide | Physarum polycephalum | |
| Ba2+ | forms complex with di- or trinucleotide | Thiobacillus denitrificans | |
| Ba2+ | forms complex with di- or trinucleotide | Citrus limon | |
| Ba2+ | forms complex with di- or trinucleotide | Blattidae | |
| Ca2+ | less effective than Mg2+ | Saccharomyces cerevisiae | |
| Ca2+ | less effective than Mg2+ | Bos taurus | |
| Ca2+ | in decreasing order of efficiency: Mg2+, Mn2+, Ca2+, Co2+ | Bos taurus | |
| Ca2+ | requirement, as good as Mg2+ | Saccharomyces cerevisiae | |
| Ca2+ | requirement, as good as Mg2+ | Oryctolagus cuniculus | |
| Ca2+ | in decreasing order of efficiency: Mg2+, Ca2+ Mn2+, Ba2+ | Saccharomyces cerevisiae | |
| Ca2+ | in decreasing order of efficiency: Mg2+, Ca2+ Mn2+, Ba2+ | Oryctolagus cuniculus | |
| Ca2+ | metal ion forms complex with di- or trinucleotide | Bacillus subtilis | |
| Ca2+ | metal ion forms complex with di- or trinucleotide | Mus musculus | |
| Ca2+ | metal ion forms complex with di- or trinucleotide | Escherichia coli | |
| Ca2+ | metal ion forms complex with di- or trinucleotide | Homo sapiens | |
| Ca2+ | metal ion forms complex with di- or trinucleotide | Rattus norvegicus | |
| Ca2+ | metal ion forms complex with di- or trinucleotide | Sus scrofa | |
| Ca2+ | metal ion forms complex with di- or trinucleotide | Saccharomyces cerevisiae | |
| Ca2+ | metal ion forms complex with di- or trinucleotide | Bos taurus | |
| Ca2+ | metal ion forms complex with di- or trinucleotide | Triticum aestivum | |
| Ca2+ | metal ion forms complex with di- or trinucleotide | Oryctolagus cuniculus | |
| Ca2+ | metal ion forms complex with di- or trinucleotide | Physarum polycephalum | |
| Ca2+ | metal ion forms complex with di- or trinucleotide | Thiobacillus denitrificans | |
| Ca2+ | metal ion forms complex with di- or trinucleotide | Citrus limon | |
| Ca2+ | metal ion forms complex with di- or trinucleotide | Blattidae | |
| Co2+ | requirement | Saccharomyces cerevisiae | |
| Co2+ | requirement | Bos taurus | |
| Co2+ | can replace Mg2+, Mn2+ or Ca2+ less efficiently | Bacillus subtilis | |
| Co2+ | can replace Mg2+, Mn2+ or Ca2+ less efficiently | Mus musculus | |
| Co2+ | can replace Mg2+, Mn2+ or Ca2+ less efficiently | Escherichia coli | |
| Co2+ | can replace Mg2+, Mn2+ or Ca2+ less efficiently | Homo sapiens | |
| Co2+ | can replace Mg2+, Mn2+ or Ca2+ less efficiently | Rattus norvegicus | |
| Co2+ | can replace Mg2+, Mn2+ or Ca2+ less efficiently | Sus scrofa | |
| Co2+ | can replace Mg2+, Mn2+ or Ca2+ less efficiently | Saccharomyces cerevisiae | |
| Co2+ | can replace Mg2+, Mn2+ or Ca2+ less efficiently | Bos taurus | |
| Co2+ | can replace Mg2+, Mn2+ or Ca2+ less efficiently | Triticum aestivum | |
| Co2+ | can replace Mg2+, Mn2+ or Ca2+ less efficiently | Oryctolagus cuniculus | |
| Co2+ | can replace Mg2+, Mn2+ or Ca2+ less efficiently | Physarum polycephalum | |
| Co2+ | can replace Mg2+, Mn2+ or Ca2+ less efficiently | Thiobacillus denitrificans | |
| Co2+ | can replace Mg2+, Mn2+ or Ca2+ less efficiently | Citrus limon | |
| Co2+ | can replace Mg2+, Mn2+ or Ca2+ less efficiently | Blattidae | |
| Mg2+ | requirement | Bacillus subtilis | |
| Mg2+ | requirement | Mus musculus | |
| Mg2+ | requirement | Escherichia coli | |
| Mg2+ | requirement | Homo sapiens | |
| Mg2+ | requirement | Rattus norvegicus | |
| Mg2+ | requirement | Sus scrofa | |
| Mg2+ | requirement | Saccharomyces cerevisiae | |
| Mg2+ | requirement | Bos taurus | |
| Mg2+ | requirement | Triticum aestivum | |
| Mg2+ | requirement | Oryctolagus cuniculus | |
| Mg2+ | requirement | Physarum polycephalum | |
| Mg2+ | requirement | Thiobacillus denitrificans | |
| Mg2+ | requirement | Citrus limon | |
| Mg2+ | requirement | Blattidae | |
| Mg2+ | in decreasing order of efficiency: Mg2+, Ca2+, Mn2+, Ba2+ | Saccharomyces cerevisiae | |
| Mg2+ | in decreasing order of efficiency: Mg2+, Ca2+, Mn2+, Ba2+ | Oryctolagus cuniculus | |
| Mg2+ | MgATP2- is true substrate | Bacillus subtilis | |
| Mg2+ | MgATP2- is true substrate | Mus musculus | |
| Mg2+ | MgATP2- is true substrate | Escherichia coli | |
| Mg2+ | MgATP2- is true substrate | Homo sapiens | |
| Mg2+ | MgATP2- is true substrate | Rattus norvegicus | |
| Mg2+ | MgATP2- is true substrate | Sus scrofa | |
| Mg2+ | MgATP2- is true substrate | Saccharomyces cerevisiae | |
| Mg2+ | MgATP2- is true substrate | Bos taurus | |
| Mg2+ | MgATP2- is true substrate | Triticum aestivum | |
| Mg2+ | MgATP2- is true substrate | Oryctolagus cuniculus | |
| Mg2+ | MgATP2- is true substrate | Physarum polycephalum | |
| Mg2+ | MgATP2- is true substrate | Thiobacillus denitrificans | |
| Mg2+ | MgATP2- is true substrate | Citrus limon | |
| Mg2+ | MgATP2- is true substrate | Blattidae | |
| Mg2+ | enzymatic reaction resembles inorganic metal catalysis | Bacillus subtilis | |
| Mg2+ | enzymatic reaction resembles inorganic metal catalysis | Mus musculus | |
| Mg2+ | enzymatic reaction resembles inorganic metal catalysis | Escherichia coli | |
| Mg2+ | enzymatic reaction resembles inorganic metal catalysis | Homo sapiens | |
| Mg2+ | enzymatic reaction resembles inorganic metal catalysis | Rattus norvegicus | |
| Mg2+ | enzymatic reaction resembles inorganic metal catalysis | Sus scrofa | |
| Mg2+ | enzymatic reaction resembles inorganic metal catalysis | Saccharomyces cerevisiae | |
| Mg2+ | enzymatic reaction resembles inorganic metal catalysis | Bos taurus | |
| Mg2+ | enzymatic reaction resembles inorganic metal catalysis | Triticum aestivum | |
| Mg2+ | enzymatic reaction resembles inorganic metal catalysis | Oryctolagus cuniculus | |
| Mg2+ | enzymatic reaction resembles inorganic metal catalysis | Physarum polycephalum | |
| Mg2+ | enzymatic reaction resembles inorganic metal catalysis | Thiobacillus denitrificans | |
| Mg2+ | enzymatic reaction resembles inorganic metal catalysis | Citrus limon | |
| Mg2+ | enzymatic reaction resembles inorganic metal catalysis | Blattidae | |
| Mg2+ | MgADP- is true substrate | Bacillus subtilis | |
| Mg2+ | MgADP- is true substrate | Mus musculus | |
| Mg2+ | MgADP- is true substrate | Escherichia coli | |
| Mg2+ | MgADP- is true substrate | Homo sapiens | |
| Mg2+ | MgADP- is true substrate | Rattus norvegicus | |
| Mg2+ | MgADP- is true substrate | Sus scrofa | |
| Mg2+ | MgADP- is true substrate | Saccharomyces cerevisiae | |
| Mg2+ | MgADP- is true substrate | Bos taurus | |
| Mg2+ | MgADP- is true substrate | Triticum aestivum | |
| Mg2+ | MgADP- is true substrate | Oryctolagus cuniculus | |
| Mg2+ | MgADP- is true substrate | Physarum polycephalum | |
| Mg2+ | MgADP- is true substrate | Thiobacillus denitrificans | |
| Mg2+ | MgADP- is true substrate | Citrus limon | |
| Mg2+ | MgADP- is true substrate | Blattidae | |
| Mg2+ | in decreasing order of efficiency: Mg2+, Mn2+, Ca2+, Co2+ | Bos taurus | |
| Mg2+ | forms complex with di- or trinucleotide | Bacillus subtilis | |
| Mg2+ | forms complex with di- or trinucleotide | Mus musculus | |
| Mg2+ | forms complex with di- or trinucleotide | Escherichia coli | |
| Mg2+ | forms complex with di- or trinucleotide | Homo sapiens | |
| Mg2+ | forms complex with di- or trinucleotide | Rattus norvegicus | |
| Mg2+ | forms complex with di- or trinucleotide | Sus scrofa | |
| Mg2+ | forms complex with di- or trinucleotide | Saccharomyces cerevisiae | |
| Mg2+ | forms complex with di- or trinucleotide | Bos taurus | |
| Mg2+ | forms complex with di- or trinucleotide | Triticum aestivum | |
| Mg2+ | forms complex with di- or trinucleotide | Oryctolagus cuniculus | |
| Mg2+ | forms complex with di- or trinucleotide | Physarum polycephalum | |
| Mg2+ | forms complex with di- or trinucleotide | Thiobacillus denitrificans | |
| Mg2+ | forms complex with di- or trinucleotide | Citrus limon | |
| Mg2+ | forms complex with di- or trinucleotide | Blattidae | |
| Mn2+ | in decreasing order of efficiency: Mg2+, Ca2+, Mn2+, Ba2+ | Saccharomyces cerevisiae | |
| Mn2+ | in decreasing order of efficiency: Mg2+, Ca2+, Mn2+, Ba2+ | Oryctolagus cuniculus | |
| Mn2+ | in decreasing order of efficiency: Mg2+, Mn2+, Ca2+, Co2+ | Bos taurus | |
| Mn2+ | forms complex with di- or trinucleotide | Bacillus subtilis | |
| Mn2+ | forms complex with di- or trinucleotide | Mus musculus | |
| Mn2+ | forms complex with di- or trinucleotide | Escherichia coli | |
| Mn2+ | forms complex with di- or trinucleotide | Homo sapiens | |
| Mn2+ | forms complex with di- or trinucleotide | Rattus norvegicus | |
| Mn2+ | forms complex with di- or trinucleotide | Sus scrofa | |
| Mn2+ | forms complex with di- or trinucleotide | Saccharomyces cerevisiae | |
| Mn2+ | forms complex with di- or trinucleotide | Bos taurus | |
| Mn2+ | forms complex with di- or trinucleotide | Triticum aestivum | |
| Mn2+ | forms complex with di- or trinucleotide | Oryctolagus cuniculus | |
| Mn2+ | forms complex with di- or trinucleotide | Physarum polycephalum | |
| Mn2+ | forms complex with di- or trinucleotide | Thiobacillus denitrificans | |
| Mn2+ | forms complex with di- or trinucleotide | Citrus limon | |
| Mn2+ | forms complex with di- or trinucleotide | Blattidae | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 21000 | - |
muscle, sedimentation and diffusion | Oryctolagus cuniculus |
| 21000 | - |
eye lens | Bos taurus |
| 21300 | - |
- |
Homo sapiens |
| 21300 | - |
muscle | Sus scrofa |
| 21500 | - |
- |
Homo sapiens |
| 21500 | - |
liver mitochondria | Bos taurus |
| 23000 | - |
- |
Homo sapiens |
| 23000 | - |
isozyme III, at concentrations above 3 mg/ml, dimers and trimers of MW 46000 and 68000 are formed | Rattus norvegicus |
| 41000 | - |
- |
Saccharomyces cerevisiae |
| 46000 | 49000 | isozyme II | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + ADP | Bacillus subtilis | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | ? | - |
r | |
| ADP + ADP | Mus musculus | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | ? | - |
r | |
| ADP + ADP | Escherichia coli | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | ? | - |
r | |
| ADP + ADP | Homo sapiens | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | ? | - |
r | |
| ADP + ADP | Rattus norvegicus | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | ? | - |
r | |
| ADP + ADP | Sus scrofa | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | ? | - |
r | |
| ADP + ADP | Saccharomyces cerevisiae | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | ? | - |
r | |
| ADP + ADP | Bos taurus | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | ? | - |
r | |
| ADP + ADP | Triticum aestivum | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | ? | - |
r | |
| ADP + ADP | Oryctolagus cuniculus | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | ? | - |
r | |
| ADP + ADP | Physarum polycephalum | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | ? | - |
r | |
| ADP + ADP | Thiobacillus denitrificans | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | ? | - |
r | |
| ADP + ADP | Citrus limon | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | ? | - |
r | |
| ADP + ADP | Blattidae | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | ? | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
| Blattidae | - |
- |
- |
| Bos taurus | - |
- |
- |
| Citrus limon | - |
lemon, sweet and sour | - |
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
normal or with genetically induced muscular dystrophy | - |
| Oryctolagus cuniculus | - |
- |
- |
| Physarum polycephalum | - |
slime mold | - |
| Rattus norvegicus | - |
adult or neonatal | - |
| Saccharomyces cerevisiae | - |
- |
- |
| Sus scrofa | - |
- |
- |
| Thiobacillus denitrificans | - |
- |
- |
| Triticum aestivum | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bacillus subtilis |
- |
Saccharomyces cerevisiae |
- |
Blattidae |
| liver enzyme, 4 isozymes | Rattus norvegicus |
| liver mitochondria, eye lens | Bos taurus |
| muscle | Homo sapiens |
| muscle | Sus scrofa |
| muscle | Oryctolagus cuniculus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + AMP = 2 ADP | mechanism | Mus musculus | |
| ATP + AMP = 2 ADP | mechanism | Rattus norvegicus | |
| ATP + AMP = 2 ADP | mechanism | Sus scrofa | |
| ATP + AMP = 2 ADP | mechanism | Bos taurus | |
| ATP + AMP = 2 ADP | mechanism | Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| brain | - |
Sus scrofa | - |
| brain | - |
Bos taurus | - |
| brain | - |
Oryctolagus cuniculus | - |
| erythrocyte | - |
Homo sapiens | - |
| erythrocyte | - |
Oryctolagus cuniculus | - |
| fruit | - |
Citrus limon | - |
| heart | - |
Mus musculus | - |
| heart | - |
Homo sapiens | - |
| heart | - |
Rattus norvegicus | - |
| heart | - |
Sus scrofa | - |
| heart | - |
Bos taurus | - |
| heart | - |
Oryctolagus cuniculus | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| kidney | - |
Oryctolagus cuniculus | - |
| leaf | - |
Triticum aestivum | - |
| leaf | - |
Citrus limon | - |
| leukocyte | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
| liver | - |
Oryctolagus cuniculus | - |
| lung | - |
Homo sapiens | - |
| additional information | - |
Bacillus subtilis | - |
| additional information | - |
Escherichia coli | - |
| additional information | - |
Saccharomyces cerevisiae | - |
| additional information | - |
Physarum polycephalum | - |
| additional information | - |
Thiobacillus denitrificans | - |
| additional information | tissue distribution | Mus musculus | - |
| additional information | tissue distribution | Homo sapiens | - |
| additional information | tissue distribution | Rattus norvegicus | - |
| additional information | tissue distribution | Sus scrofa | - |
| additional information | tissue distribution | Bos taurus | - |
| additional information | tissue distribution | Triticum aestivum | - |
| additional information | tissue distribution | Oryctolagus cuniculus | - |
| additional information | tissue distribution | Citrus limon | - |
| additional information | tissue distribution | Blattidae | - |
| additional information | rabbit and human carry a minimum of 2 sets of isozymes within an individual: one set in muscle, erythrocytes, brain and another in liver, kidney and spleen | Homo sapiens | - |
| additional information | rabbit and human carry a minimum of 2 sets of isozymes within an individual: one set in muscle, erythrocytes, brain and another in liver, kidney and spleen | Oryctolagus cuniculus | - |
| additional information | high activities in tissues where turnover of energy from adenine nucleotides is great, e. g. muscle | Homo sapiens | - |
| additional information | high activities in tissues where turnover of energy from adenine nucleotides is great, e. g. muscle | Sus scrofa | - |
| additional information | high activities in tissues where turnover of energy from adenine nucleotides is great, e. g. muscle | Oryctolagus cuniculus | - |
| muscle | - |
Mus musculus | - |
| muscle | - |
Homo sapiens | - |
| muscle | - |
Rattus norvegicus | - |
| muscle | - |
Sus scrofa | - |
| muscle | - |
Bos taurus | - |
| muscle | - |
Oryctolagus cuniculus | - |
| muscle | - |
Blattidae | - |
| skin | neonatal rats | Rattus norvegicus | - |
| spleen | - |
Homo sapiens | - |
| spleen | - |
Oryctolagus cuniculus | - |
| spore | - |
Bacillus subtilis | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 60 | - |
isozyme II | Rattus norvegicus |
| 1000 | - |
liver isozyme III | Rattus norvegicus |
| 1062 | - |
liver, mitochondria | Bos taurus |
| 1810 | - |
muscle | Sus scrofa |
| 1900 | - |
- |
Rattus norvegicus |
| 1900 | - |
- |
Saccharomyces cerevisiae |
| 1920 | - |
muscle | Homo sapiens |
| 2200 | - |
muscle | Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + ADP | - |
Bacillus subtilis | ATP + AMP | - |
r | |
| ADP + ADP | - |
Mus musculus | ATP + AMP | - |
r | |
| ADP + ADP | - |
Escherichia coli | ATP + AMP | - |
r | |
| ADP + ADP | - |
Homo sapiens | ATP + AMP | - |
r | |
| ADP + ADP | - |
Rattus norvegicus | ATP + AMP | - |
r | |
| ADP + ADP | - |
Sus scrofa | ATP + AMP | - |
r | |
| ADP + ADP | - |
Saccharomyces cerevisiae | ATP + AMP | - |
r | |
| ADP + ADP | - |
Bos taurus | ATP + AMP | - |
r | |
| ADP + ADP | - |
Triticum aestivum | ATP + AMP | - |
r | |
| ADP + ADP | - |
Oryctolagus cuniculus | ATP + AMP | - |
r | |
| ADP + ADP | - |
Physarum polycephalum | ATP + AMP | - |
r | |
| ADP + ADP | - |
Thiobacillus denitrificans | ATP + AMP | - |
r | |
| ADP + ADP | - |
Citrus limon | ATP + AMP | - |
r | |
| ADP + ADP | - |
Blattidae | ATP + AMP | - |
r | |
| ADP + ADP | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | Bacillus subtilis | ? | - |
r | |
| ADP + ADP | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | Mus musculus | ? | - |
r | |
| ADP + ADP | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | Escherichia coli | ? | - |
r | |
| ADP + ADP | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | Homo sapiens | ? | - |
r | |
| ADP + ADP | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | Rattus norvegicus | ? | - |
r | |
| ADP + ADP | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | Sus scrofa | ? | - |
r | |
| ADP + ADP | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | Saccharomyces cerevisiae | ? | - |
r | |
| ADP + ADP | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | Bos taurus | ? | - |
r | |
| ADP + ADP | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | Triticum aestivum | ? | - |
r | |
| ADP + ADP | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | Oryctolagus cuniculus | ? | - |
r | |
| ADP + ADP | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | Physarum polycephalum | ? | - |
r | |
| ADP + ADP | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | Thiobacillus denitrificans | ? | - |
r | |
| ADP + ADP | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | Citrus limon | ? | - |
r | |
| ADP + ADP | facilitates storage and use of the high energy of the adenine nucleotides, involved in maintenance of equilibrium among adenine nucleotides and maintenance of energy charge, important to energy economy of living systems | Blattidae | ? | - |
r | |
| ATP + AMP | highly specific | Rattus norvegicus | ADP + ADP | - |
r | |
| ATP + AMP | substrates in decreasing order of activity, in the presence of Mn2+: ATP, 2'-dATP, CTP, GTP, UTP, ITP | Oryctolagus cuniculus | ADP + ADP | - |
r | |
| ATP + AMP | specificity for AMP-site is much more rigorous than for ATP-site | Bacillus subtilis | ADP + ADP | - |
r | |
| ATP + AMP | specificity for AMP-site is much more rigorous than for ATP-site | Mus musculus | ADP + ADP | - |
r | |
| ATP + AMP | specificity for AMP-site is much more rigorous than for ATP-site | Escherichia coli | ADP + ADP | - |
r | |
| ATP + AMP | specificity for AMP-site is much more rigorous than for ATP-site | Homo sapiens | ADP + ADP | - |
r | |
| ATP + AMP | specificity for AMP-site is much more rigorous than for ATP-site | Rattus norvegicus | ADP + ADP | - |
r | |
| ATP + AMP | specificity for AMP-site is much more rigorous than for ATP-site | Sus scrofa | ADP + ADP | - |
r | |
| ATP + AMP | specificity for AMP-site is much more rigorous than for ATP-site | Saccharomyces cerevisiae | ADP + ADP | - |
r | |
| ATP + AMP | specificity for AMP-site is much more rigorous than for ATP-site | Bos taurus | ADP + ADP | - |
r | |
| ATP + AMP | specificity for AMP-site is much more rigorous than for ATP-site | Triticum aestivum | ADP + ADP | - |
r | |
| ATP + AMP | specificity for AMP-site is much more rigorous than for ATP-site | Oryctolagus cuniculus | ADP + ADP | - |
r | |
| ATP + AMP | specificity for AMP-site is much more rigorous than for ATP-site | Physarum polycephalum | ADP + ADP | - |
r | |
| ATP + AMP | specificity for AMP-site is much more rigorous than for ATP-site | Thiobacillus denitrificans | ADP + ADP | - |
r | |
| ATP + AMP | specificity for AMP-site is much more rigorous than for ATP-site | Citrus limon | ADP + ADP | - |
r | |
| ATP + AMP | specificity for AMP-site is much more rigorous than for ATP-site | Blattidae | ADP + ADP | - |
r | |
| ATP + AMP | substrates in decreasing order of activity, in the presence of Mg2+: ATP, dATP, GTP, ITP | Saccharomyces cerevisiae | ADP + ADP | - |
r | |
| ITP + AMP | - |
Bos taurus | IDP + ADP | - |
? | |
| ITP + AMP | poor substrate | Saccharomyces cerevisiae | IDP + ADP | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | isozyme III, at concentrations above 3 mg/ml, dimers and trimers of MW 46000 and 68000 are formed | Rattus norvegicus |
| trimer | isozyme III, at concentrations above 3 mg/ml, dimers and trimers of MW 46000 and 68000 are formed | Rattus norvegicus |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Oryctolagus cuniculus | muscle enzyme | - |
6.1 |
| Rattus norvegicus | liver type enzymes | - |
7.5 |
| Bos taurus | liver type enzymes | - |
7.5 |
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Release 2023.1 (January 2023)
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