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Literature summary for 2.7.4.6 extracted from

  • Baughman, C.; Morin-Leisk, J.; Lee, T.
    Nucleoside diphosphate kinase B (NDKB) scaffolds endoplasmic reticulum membranes in vitro (2008), Exp. Cell Res., 314, 2702-2714.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
K56E/R58E site-directed mutation of the residues required for membrane phospholipid binding, the NDKB mutant is defective in anionic phospholipid binding Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum membrane
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Rattus norvegicus 5789
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme is involved in endoplasmic reticulum membranes structure formation, the mechanism of membrane extension involves direct lipid binding, as NDKB-bound phosphatidylinositol-4-phosphate, phosphatidylinositol-4,5-diphosphate, and phosphatidic acid. Binding to these anionic lipids requires clusters of basic residues on the surface of the NDKB hexamer. Amino acid changes in NDKB, that block lipid binding, also block endoplasmic reticulum network extension, overview ?
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
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Rattus norvegicus
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kidney
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Rattus norvegicus
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NRK cell
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in endoplasmic reticulum membranes structure formation, the mechanism of membrane extension involves direct lipid binding, as NDKB-bound phosphatidylinositol-4-phosphate, phosphatidylinositol-4,5-diphosphate, and phosphatidic acid. Binding to these anionic lipids requires clusters of basic residues on the surface of the NDKB hexamer. Amino acid changes in NDKB, that block lipid binding, also block endoplasmic reticulum network extension, overview Rattus norvegicus ?
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?
additional information NDKB stabilizes an extended endoplasmic reticulum network in vitro, overview Rattus norvegicus ?
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?

Synonyms

Synonyms Comment Organism
NDKB
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Rattus norvegicus
nucleoside diphosphate kinase B
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Rattus norvegicus