Protein Variants | Comment | Organism |
---|---|---|
K56E/R58E | site-directed mutation of the residues required for membrane phospholipid binding, the NDKB mutant is defective in anionic phospholipid binding | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum membrane | - |
Rattus norvegicus | 5789 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | the enzyme is involved in endoplasmic reticulum membranes structure formation, the mechanism of membrane extension involves direct lipid binding, as NDKB-bound phosphatidylinositol-4-phosphate, phosphatidylinositol-4,5-diphosphate, and phosphatidic acid. Binding to these anionic lipids requires clusters of basic residues on the surface of the NDKB hexamer. Amino acid changes in NDKB, that block lipid binding, also block endoplasmic reticulum network extension, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
NRK cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is involved in endoplasmic reticulum membranes structure formation, the mechanism of membrane extension involves direct lipid binding, as NDKB-bound phosphatidylinositol-4-phosphate, phosphatidylinositol-4,5-diphosphate, and phosphatidic acid. Binding to these anionic lipids requires clusters of basic residues on the surface of the NDKB hexamer. Amino acid changes in NDKB, that block lipid binding, also block endoplasmic reticulum network extension, overview | Rattus norvegicus | ? | - |
? | |
additional information | NDKB stabilizes an extended endoplasmic reticulum network in vitro, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NDKB | - |
Rattus norvegicus |
nucleoside diphosphate kinase B | - |
Rattus norvegicus |