Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
foreskin | - |
Homo sapiens | - |
HBE135-E6E7 cell | - |
Homo sapiens | - |
HEK-293T cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
keratinocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + GDP | - |
Homo sapiens | ADP + GTP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NDK | - |
Homo sapiens |
Nm23-H1 | - |
Homo sapiens |
nucleoside diphosphate kinase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | loss of Nm23-H1 in diploid cells leads to cytokinetic furrow regression, followed by cytokinesis failure and generationof tetraploid cells. The loss of Nm23-H1, an event suspected to promote metastasis, additionally functions at an earlier stage of tumor development to drive the acquisition of chromosomal instability | Homo sapiens |
physiological function | nucleoside diphosphate kinase Nm23-H1 regulates chromosomal stability by activating the GTPase dynamin during cytokinesis | Homo sapiens |