Crystallization (Comment) | Organism |
---|---|
TMPK bound to TDP and to brivudin monophosphate, hanging drop vapor diffusion method | Vaccinia virus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(E)-5-(2-bromovinyl)-deoxyuridine | - |
Vaccinia virus | |
5-bromo-deoxyuridine | - |
Vaccinia virus | |
5-chloro-deoxyuridine | - |
Vaccinia virus | |
5-fluoro-deoxyuridine | - |
Vaccinia virus | |
5-iodo-deoxyuridine | - |
Vaccinia virus | |
deoxythymidine | - |
Vaccinia virus | |
deoxyuridine | - |
Vaccinia virus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.19 | - |
(E)-5-(2-bromovinyl)-deoxyuridine monophosphate | - |
Vaccinia virus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | contains Mg2+ at the active site | Vaccinia virus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Vaccinia virus | P68693 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (E)-5-(2-bromovinyl)-deoxyuridine monophosphate | 5% of the TMP efficiency | Vaccinia virus | ? | - |
? | |
ATP + brivudin | - |
Vaccinia virus | ? | - |
? | |
ATP + dGMP | 5% of the TMP efficiency | Vaccinia virus | ? | - |
? | |
ATP + dUMP | - |
Vaccinia virus | ? | - |
? | |
ATP + TMP | - |
Vaccinia virus | ? | - |
? | |
N-methanocarbathymidine | - |
Vaccinia virus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | x-ray crystallography | Vaccinia virus |
Synonyms | Comment | Organism |
---|---|---|
thymidylate kinase | - |
Vaccinia virus |
TMPK | - |
Vaccinia virus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
42.5 | - |
the midtemperature of thermal denaturation is 42.5°C | Vaccinia virus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.86 | - |
(E)-5-(2-bromovinyl)-deoxyuridine monophosphate | - |
Vaccinia virus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Vaccinia virus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.007 | - |
5-bromo-deoxyuridine | - |
Vaccinia virus | |
0.015 | - |
5-chloro-deoxyuridine | - |
Vaccinia virus | |
0.023 | - |
5-iodo-deoxyuridine | - |
Vaccinia virus | |
0.025 | - |
deoxythymidine | - |
Vaccinia virus | |
0.5 | - |
(E)-5-(2-bromovinyl)-deoxyuridine | - |
Vaccinia virus | |
0.7 | - |
5-fluoro-deoxyuridine | - |
Vaccinia virus | |
1 | - |
deoxyuridine | - |
Vaccinia virus |