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Literature summary for 2.7.6.1 extracted from
- Binding of divalent magnesium by Escherichia coli phosphoribosyl diphosphate synthetase (1997), Biochemistry, 36, 5078-5083.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | inhibition even in presence of excess Mg2+ | Escherichia coli |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | prepares the active site of the enzyme for the binding of the highly phosphorylated ligands | Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate | steady state ordered mechanism in which Mg2+ binds first and D-ribose 5-phosphate binds last | Escherichia coli |
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